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MD3001 > Drug Distribution > Flashcards

Flashcards in Drug Distribution Deck (6)
1

What are the factors that affect drug distribution?

CO & blood flow
Plasma protein binding
Lipid solubility
Drug ionisation
pH of compartments
Capillary permeability

2

Out of the factors listed in the previous question, which is the one that INITIAL drug distribution is heavily dependant on?

Blood flow

3

What is albumin?

The predominate plasma binding protein

4

How do lipid soluble drugs and weak acids respectively, bind to albumin?

Non-specificlly
Specifically to a saturable site

5

What property can some drugs have which can prevent them from crossing the cell membrane?

Ionised

6

How is the apparent volume of distribution of a drug calculated (Vd)?

Total amount of drug in the body/Blood plasma concentration of drug

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