Flashcards in Drug Distribution Deck (6)
What are the factors that affect drug distribution?
CO & blood flow
Plasma protein binding
pH of compartments
Out of the factors listed in the previous question, which is the one that INITIAL drug distribution is heavily dependant on?
What is albumin?
The predominate plasma binding protein
How do lipid soluble drugs and weak acids respectively, bind to albumin?
Specifically to a saturable site
What property can some drugs have which can prevent them from crossing the cell membrane?