Treatment of Arrhythmias Flashcards Preview

MD3001 > Treatment of Arrhythmias > Flashcards

Flashcards in Treatment of Arrhythmias Deck (19)
1

What 3 factors contribute to the spontaneous electrical discharge of the SAN?

o Decrease in K+ outflow
o “funny” Na+ current
o Slow inward Ca2+ current

2

Which area of the heart are atrial dysrhythmias associated with?

Supraventricular

3

Which area of the heart are junctional dysrhythmias associated with?

AV node

4

What are the 4 broad categories of event that dysrhythmias usually arise from?

Heart block
After depolarisations (early or delayed)
Circuit re-entry
Ectopic pacemaker activity

5

Which class of arrhythmia treatment do potassium channel blockers belong to?

Class 3

6

Which class of arrhythmia treatment do calcium channel blockers belong to?

Class 4

7

Which class of arrhythmia treatment do sodium channel blockers belong to?

Class 1

8

Which class of arrhythmia treatment do beta-adrenoreceptor channel blockers belong to?

Class 2

9

Sotalol

Class 2

10

Verapamil

Class 4

11

Disopyramide

Class 1a

12

Flecainide

Class 1c

13

Amiodarone

Class 3

14

Lignocaine

Class 1b

15

What are the two important arrhythmia treating drugs that are 'unclassified'?

Adenosine
Digoxin

16

What type of dysrhythmias are very effectively tackled by verapamil?

SVT
AF

17

How does diltiazem differ from verapamil?

Diltiazem has a greater effect on smooth muscle calcium channels

18

Think back to the different phases of heart muscle contraction:

Phase 0: rapid depolarisation (F-type Na+ open)
Phase 1: partial repolarisation (F-type Na+ close)
Phase 2: plateau (Ca2+ open)
Phase 3: repolarisation (Ca2+ close, K+ open)
Phase 4: stable (pacemaker potential)

Which phases do each of the classes of anti-arrhythmic drugs target?

CLASS 1: Phase 0 (rapid depolarisation)

CLASS 2: Inhibit action of beta agonists, which act on Phase 2 (plateau) and Phase 4 (pacemaker potential)

CLASS 3 & 1a: Phase 3 (repolarisation)

CLASS 4: Phase 2 (plateau)

19

NOTE:

LOOK OVER NOTES FOR THIS LECTURE FOR ESSENTIAL FURTHER DETAIL

Decks in MD3001 Class (63):