Treatment of Hypertension Flashcards Preview

MD3001 > Treatment of Hypertension > Flashcards

Flashcards in Treatment of Hypertension Deck (30)
1

What is the advantage of using an ARB as opposed to an ACE inhibitor?

Cheaper

2

What is the disadvantage of using a thiazide like diuretic?

Lots of associated side effects

3

What do the treatment drugs focus on achieving, directly, leading to reduction in BP?

Total peripheral resistance

4

Give 3 examples of ACE inhibitors.

Ramipril
Lisinopril
Captopril

5

What is the primary example of an ARB?

Losartan

6

What type of drug is aliskiren?

A renin inhibitor

7

What type of drug is amlodipine?

Calcium channel blocker

8

Give two examples of thiazide like diuretics.

Indapamine
Bendroflumethiazide

9

What type of drug is ramipril?

An ACE inhibitor

10

Give an example of a renin inhibitor.

Aliskiren

11

Give two examples of calcium channel blockers.

Amlodipine
Lercanidipine

12

What type of drug is losartan?

An ARB

13

What type of drug is lisinopril?

An ACE inhibitor

14

What type of drug is indapamine?

Thiazide like diuretic

15

What is the role of aldosterone?

To allow Na+ and Ca2+ to be reabsorbed into the interstitial fluid from the collecting duct in the kidneys

16

What is the mechanism of action of spironolactone?

Acts as a competitive inhibitor and blocks reabsorption of Na+ and Ca2+, thus acting as a diuretic, since water will follow solute

17

What is the mechanism of action of the thiazide like diuretics?

Block reabsorption of Na+ in the medulla, meaning no water will cross out of the tubules

18

Which class of drug gives the following side effects?
Persistent dry cough
Dizziness
Headaches
Tiredness

ACE inhibitors

19

Which class of drug gives the following side effects?
Flushes
Headaches
Ankle oedema
Dizziness

Calcium channel blockers

20

Which class of drug can raise potassium and blood sugar levels?

Thiazide like diuretics

21

Which class of drug gives the following side effects?
Back/leg pain
Headaches
Dizziness

ARBs

22

What three classes of anti-hypertensive drug come under the umbrella of renin-angiotensin system inhibitors?

ACE inhibitors
ARBs
Renin inhibitors

23

Give 2 example of beta blockers.

Atenolol
Bisoprolol

24

What type of drug is doxazosin

Alpha adrenoreceptor blocker

25

What type of drug is spironolactone?

Potassium sparing diuretics and aldosterone antagonists

26

What do ACE inhibitors inhibit/block?

Conversion of Angiotensin I to Angiotensin II

27

What do ARBs inhibit/block?

Block AT1 receptors and hence binding of Angiotensin II

28

By inhibiting the renin angiotensin system, what are these drugs preventing?

Vasoconstriction
Vascular growth (inc. hypertrophy)
Salt retention

29

Where in the nephron does spironolactone act?

Collecting duct

30

Where in the nephron do the thiazide like diuretics act?

Distal convoluted tubule

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