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Flashcards in Drugs Deck (32)
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Opiates: description

Narcotic analgesic
Addictive
Habit forming

1

Opiates : opium

1. Morphine
2. Codeine
3. Heroin

2

Morphine: composition

Fits into receptor sites on neurons in the brain and spinal cord

3

Morphine:

Receptor site (similar drugs sit)

Difference between morphine and codeine is very small

4

Codeine

Prescription cough syrup

Enzyme (clieves off ether turns into morphine)

Converted to morphine

5

Heroine

Morphine and esters (not polar, no H-bonds. Esters)

100x easier to pass BBB

Very addictive

6

Synthetic opiates

Add addictive milder than morphine

7

Demerol

Shot

Synthetic opiate

8

Hydrocodone

Percodan
Percoset
OxyContin (10 x time release)

Synthetic opiates

9

Addiction

1. Psychological dependence
2. Physiological dependence
3. Tolerance

10

Psychological dependence

Uncontrolled desire for drug

11

Physiological dependence

Body need the drug

12

Withdrawal

Leads to convulsions

More dangerous than drug

13

Tolerance

User increases dosage to get the same effect.

Body decreases number of receptor sites (defense against drug)

14

Cocaine is worse. Why

Dopamine

Decrease receptors

Depression

15

Narcotic analgesics

Morphine

Demerol

Oxycodon: Percodan
Percosel
OxyContin
Fentanyl patch

16

Fentanyl patch

80% stronger than morphine

17

Antagonist

Molecule that BLOCKS the receptor for a drug neurotransmitter

18

Agonist

Molecule MIMICS the action of the drug or neurotransmitter

19

Treatment of addiction

Methadone

Naloxone

20

Methadone

Highly addictive

Clinic

Treat heroin overdose

21

Naloxone

Antagonist to heroin
(Blocks the receptor)

No high associated

22

Why we have opiate receptors

Body has own opiates (pain killers)

23

Produce opiates

Endorphins

Enkaphalins

(Receptors)

24

Endorphins

1. Respond to pain DEEP in the body. Wound (kills pain)

2. Runners "high" ~ strenuous physical activity

3. Acupuncture~ deep, produce endorphins

25

Enkephalins
Endorphins

Acts as pain blockers

Produced by the body

Involved in pain perception

Inhibits intestinal motility

26

Morphine

--One of the most effective painkillers
--Acts by blocking the process in the brain that interprets pain signals from peripheral nervous system

Brain has receptor sites for the body own opiates (enkephalins) and morphine fits into those receptor sites

27

Codeine

Less potent than morphine

Used in cough syrup

Enzyme that converts the codeine into morphine

28

Oxycodone and Hydrocodone

Synthetic pain killer

Found in Percodan
Percocet
Oxycotin

29

Heroin

Illegal drug produced from morphine

3x more potent than morphine (ability to move through the BBB)

More addictive than morphine used in Bayer aspirin products 1880s

30

Naloxone

Used to treat heroin overdoing

Blocks receptors sites for opiates
Antagonist

31

Buprenorphine

Helps with opiate addictions

Binds to same sites as heroin but with no "high"

Less addictive and easier withdrawal