Kreb Cycle Flashcards Preview

Biochem > Kreb Cycle > Flashcards

Flashcards in Kreb Cycle Deck (20)
0

Step 1

Acetyl group is transferred from

Acetyl-SCoA

To

Oxaloacetate

Produced in step 8

1

Step 2

Citrate is

Isomerized by

Transfer of OH group to yield

Isocitrate

2

Step 3

Isocitrate loses

CO2
And is

Oxidized to yield
Alpha- ketoglutarate

3

Step 4

Alpha-ketoglutarate
Reacts with

Coenzyme A
And loses
CO2 to yield
Succinyl-SCoA

4

Step 5
Succinyl-CoA is set

Free to give
Succinate
Plus
CoA
In a reaction coupled with
ATP formation

5

Step 6
Two hydrogens

Are removed from
Succinate
To yield
Fumarate

6

Step 7
Addition of water

To the double bond of
Fumarate yields
Malate

7

Step 8
The cycle of reactions

Is completed by

Oxidation of malate to
Regenerate
Oxaloacetate

8

Acetyl CoA available from the

Breakdown of
Carbohydrates
Lipids
Amino acids

9

Acetyl CoA is the

Fuel of the citric acid cycle

10

The operation of the cycle requires a supply of the

Oxidizing agents
NAD and FAD

11

The cycle is dependent on

Reactions of the electron transport chain

12

the electron transport chain supplys

The necessary
NAD
FAD

13

In each turn of the cycle

Acetyl CoA enters and two fully oxidized carbon molecules leave as CO2

14

Acetyl-CoA
From the

Glycolytic pathway
or
From fatty acid catabolism

15

Three molecules of

NAD

16

One molecule of

FAD

17

Three molecules of NAD and one molecule of FAD are

Reduced

18

One molecule of GTP

Is generated in a
Substrate level phosphorylation reaction

19

GTP

Interconvertible with ATP