Drugs that interfere with electron transport chain Flashcards Preview

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Flashcards in Drugs that interfere with electron transport chain Deck (14):
1

Who are the electron transport inhibitors?

Rotenone
cyanide
antimycin A
CO

2

Who are the ATP synthase inhibitors

Oligomycin

3

Who are the uncoupling agents

2,4 Dinitrophenol (2,4 DNP)
Aspirin
Thermogenin (brown fat)

4

what is the mechanism of the electron transport inhibitors?

directly inhibit electron transport causing a decrease in proton gradient and blocking ATP synthesis

5

What is the mechanism of the ATP synthase inhibitors

Directly inhibit mitochondrial ATP synthase, causing an increase proton gradient. No ATP is produced because electron transport stops.

6

What is the mechanism behind uncoupling agents

increase permeability of the membrane causing a decrease in the proton gradient and increase in O2 consumption.

ATP synthesis stops
Electron transport continues

Produces HEAT

7

Where does Rotenone inhibit?

Complex 1 : NADH reductase

rotenone is an insecticide/ fish poison

8

Amytal?

Complex 1: NADH reductase

9

MMP?

Complex 1: NADH reductase

Recall that it can cause Parkinsonism like features

10

Antimycin A blocks who?

Complex III: Cytochrome b+ c1

11

Cyanide (CN-) blocks?

Complex 4: Cytochrome a+ a3

12

CO blocks who in the electron transport chain?

Complex 4: Cytochrome a+ a3

13

H2S and N3- block who in the electron transport chain

Complex 4: Cytochrome a+ a3

14

What is the treatment for lung abscesses?

Clindamycin