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Drug Reactions > ENDO > Flashcards

Flashcards in ENDO Deck (12):
1

Glucocorticoids

(3: 2 + 1 from withdrawal)?

- Fat redistribution
- Myopathies

- (withdrawal) -> Adrenocortical insuf

2

Propylthiouracil (4)

- Agranulocytosis
- Aplastic Anemia
- Hepatotoxicity
- Skin rash

3

Methimazole

Agranulocytosis

4

1st-Generation Sulfonylureas

Disulfiram-like reaction

5

Glitazones / Thiazolidinediones (4)

- Edema
- Weight gain
- Heart failure
- Hepatotoxicity

6

GLP-1 Analogs

Pancreatitis

7

Metformin (2)

CI (2)?

- Lactic Acidosis (therefore CI in renal failure)
- GI upset

CI:
- Renal failure
- Use with contrast dyes (ie in imaging studies)

8

Drug that causes Adrenocortical Insuf?

Glucocorticoid WITHDRAWAL (HPA suppression)

9

Drugs that cause Cushing-like Sx

(2)?

- Prednisone
- Prednisolone

(Corticosteroids = #1 exogenous cause of Cushing's. Lead to bilateral adrenal atrophy +↓ACTH secretion thr negative feedback.)

10

Demeclocycline (3)

* - Nephrogenic DI
- Bone / Teeth abnormalities
- Photosensitivity

11

Drugs that cause Hyperglycemia

(4)?

- Diazoxide
- Niacin
- Protease Inhibitors
- Tacrolimus (immunosuppressant)

12

Drugs that cause Hypothyroidism

(3)?

- Amiodarone
- Lithium
- Sulfonamides