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Flashcards in MSK Deck (23):
1

Aspirin and NSAIDs (3 COMMON)

- Hemolysis in G6PD-deficient patients
- Gastric Ulceration and Upper GI Bleeding
- Interstitial Nephritis and Renal Ischemia / Acute Renal Failure

2

Aspirin (3 UNIQUE)

- Resp Alkalosis (early) -> Mixed Resp Alkalosis/Metab Acidosis (late)
- Reye Sx (PEDS)
- Tinnitus

3

NSAIDs (3)?

- Aplastic Anemia
- Gastric Ulceration and Upper GI Bleeding (due to its PGE1 inhibition)
- Interstitial Nephritis and Renal Ischemia / Acute Renal Failure
(due to its PGE1 inhibition)

4

Acetaminophen

Hepatic Necrosis

(Acetaminophen metabolite depletes Glutathione + forms toxic adducts in Liver)

5

Allopurinol

CI?

Stevens-Johnson Sx

CI:
- Salicylates

6

Celecoxib (2)?

- Sulfa allergy
-↑risk of thrombosis

7

Colchicine (2)?

- Agranulocytosis
- Myopathies

7

Bisphosphonates (2)?

- Corrosive Esophagitis
- Osteonecrosis of Jaw

8

Corticosteroids (4: 1 msk + 3 heme)

- Osteoporosis / Osteonecrosis (high-dose)
- Neutrophilia (impair migration of neutrophils out of vasculature
by↓activation of neutrophil adhesion molecules)
- Eosinopenia (sequester eosinophils in lymph nodes)
- Lymphopenia (cause apoptosis of lymphocytes)

9

Prednisone

Rhabdomyolysis

10

Probenecid (2)?

- Uric acid calculi (inhib reabs of uric acid in PCT)
- Inhib secretion of Penicillin

11

TNF-a Inhibitors

Predispose to infection (ie reactivation of latent TB)

(Inhibiting TNF-a -> NO activation of Macrophages ->
NO degradation of phagocytosed microbes)

12

Drugs that cause Fat Redistribution (2)?

- Glucocorticoids
- Protease Inhibitors

13

Drugs that cause Gingival Hyperplasia (2)?

- Phenytoin
- Verapamil

14

Drugs that cause Gout (5)?

- Cyclosporin
- Niacin
- Pyrazinamide
- Furosemide
- Thiazides

15

Drugs that cause Myopathies (8)?

- Glucocorticoids
- Fibrates
- Niacin
- Statins
- Colchicine
- Interferon-a
- Penicillamine
- Hydroxychloroquine

16

Drugs that cause Osteoporosis (2)?

- Corticosteroids
- Heparin

17

Drugs that cause Photosensitivity (3: "SAT for a photo")?

- Sulfonamides
- Amiodarone
- Tetracycline

18

Drugs that cause Rash (6: 4 Antibiotics + 2 Antivirals)?

- Aminopenicillins
- Carbapenems
- Macrolides
- Fluoroquinolones
- Tenofovir
- NNRTIs

19

Drugs that cause Rash / Stevens-Johnson Sx

(8: "bad rash after a PEC SLAPP")?

- Penicillin
- Ethosuximide
- Carbamazepine
- Sulfa drugs
- Lamotrigine
- Allopurinol
- Phenytoin
- Phenobarbital

20

Drugs that cause Rhabdomyolysis

(5: "F RIPS")?

- Fibrates
- Rifampin
- INH
- Prednisone
- Statins

21

Drug that causes Tendonitis / Tendon rupture +
Cartilage damage?

Fluoroquinolones

22

Drugs that cause SLE-like sx (4)?

- Hydralazine
- Procainamide
- Phenytoin
- INH