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Flashcards in IMMUNO Deck (12):
0

Cyclosporine (6)

- Predisposition to viral infections + lymphomas
- Neurotoxicity (ie peripheral neuropathy)
- Nephrotoxicity
- Htn
- Hyperglycemia
- Gout

1

Tacrolimus (3)

- (Cyclosporin S/E)
- Gingivial Hyperplasia
- Hirsutism

2

Sirolimus / Rapamycin (2)

- Thrombocytopenia + Leukopenia
* - Hyperlipidemia

3

Azathioprine

CI?

(Active metabolite = mercaptopurine. Mercaptopurine metab by Xanthine Oxidase.)

CI:
- Allopurinol

4

Muromonab-CD3 / OKT3

Cytokine-Release Sx

5

Interferon-a

Myopathies

6

Trastuzumab / Herceptin

Cardiotoxicity

7

Natalizumab / Rituximab

↑risk of PML (esp in patients w JC virus)

8

Thalidamide / Contergan

Phocomelia (full range of fetal devel problems)

9

BCG Vaccine

Comp?

COMP:
- IL-12 receptor def (T-cell disorder)

10

Rabies or Smallpox Vaccines

Acute Disseminated Encephalomyelitis

11

Anti-TNF Drugs (Adalimu- + Infliximab, Etanercept, Thalidamide)

Precaution?

Granuloma B/D -> Disseminated dz.

PRECAUTION:
Test for Granulomatous Dz (eg latent TB) before starting.