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Flashcards in GI Deck (16):
1

Metoclopramide

Parkinson-like sx

2

Cimetidine + Ranitidine

↑Bl Creatinine (by↓its renal excretion)

3

PPIs (-prazole) (3)

- Pneumonia
- Risk of C difficile infection
- Hip fractures (↓serum Mg with long-term use)

4

Misoprostol

Diarrhea

5

Antacids (2)

*↓stomach acid *
- Hypokalemia
- Chelation +↓effectiveness of other drugs (ie Tetracycline): alteration of gastric/urinary pH OR delaying of gastric emptying

6

Cimetidine (3 Mech of Tox)

MECH OF TOX:
- Potent INHIBITOR of P450
- Antiandrogenic (ie gynecomastia, impotence,↓libido in males, prolactin release)
- BBB + BPB crossing

7

Drugs that cause Pseudomembranous Collitis

(2)?

- Ampicillin
- Clindamycin

8

Drugs that cause Cholesterol Gallstones

(2)?

- Bile Acid Resins
- Fibrates

9

Drug that causes Reye's Sx

Aspirin

10

Therapy that causes 2ry Hemochromatosis

Chronic Transfusion Therapy

11

Drug that causes Hepatitis

INH

12

Drugs (+ 1 bug) that cause Hepatic Necrosis

(4)?

- Acetaminophen
- Halothane
- Valproic acid

- Amanita phalloides

13

Drugs that cause Hepatic Adenoma

(2)?

- Anabolic Steroids
- OCPs

14

Drug Classes that cause Acute Pancreatitis

(2)?

- Steroids
- Sulfa Drugs

15

Drug class that causes Acute Cholestatic Hepatitis?

Macrolides

15

HEPATOTOXIC Drugs

(6: 3 Antibiotics + 1 Antifungal + 2 Cardio)?

- Macrolides (Acute Cholestatic Hepatitis)
- INH
- Pyrazinamide
- Terbinafine (abnormal LFTs)

- Fibrates
- Statins