NEURO

Question 0

Alzheimer’s Drugs

(4)?

Answer 0

• Dizziness
• Nausea: D, G + R
• Insomnia: D, G + R
• Confusion + Hallucinations: Memantine

Question 1

Amantadine

Answer 1

Ataxia

Question 2

Antipsychotics (2)

Answer 2

• Parkinson-like Sx

- Tardive dyskinesia

Question 4

Barbiturates

Pres (4), CI?

Answer 4

** Induces P450 and SLOWS things down. **

• P450 drug interactions
• Dependence
• Additive CNS depression with alcohol
• CV + Resp depression (can lead to death)

CI in Porphyria.

Question 5

Benzodiazepines (-lam/pam) / Nonbenzo Hypnotics (Z Drugs)

Pres (3), RX for OD?

Answer 5

PRES:

• ↓BP
• Severe postop resp depression
• Amnesia
• Ataxia + Confusion + Headaches (Z drugs)

RX for OD = Flumazenil (competitive antagonist at GABA benzo receptor)

Question 6

Brimonidine (3)

Answer 6

• Blurry vision
• Sensation of foreign object in eye
• Ocular hyperemia + pruritus

Question 6

Buproprion

Answer 6

Seizures

Question 8

Carbamazepine (3)

Answer 8

• Blood Dyscrasias (Agranulocytosis + Aplastic Anemia)
• SIADH
• Steven-Johnson Sx

Question 9

DFH (CI: 2 Types of Generalized Seizures)

Answer 9

• Myoclonic seizures

- Absence seizures

Question 10

Clozapine

Answer 10

Agranulocytosis

Question 11

Epilepsy Drugs (General / Common Toxicities) (7)

Answer 11

• Tolerance + Dependence
• Sedation
• Ataxia
• Diplopia
• Steven-Johnson Sx
• Induction of P450 + Liver Toxicity
• Teratogenicity

Question 11

Ethosuximide (3)

Answer 11

• GI distress
• Urticaria
• Steven-Johnson Sx

Question 12

Halothane

Answer 12

Hepatic necrosis

Question 14

Lamotrigine

Answer 14

Steven-Johnson Sx

Question 15

Latanoprost

Answer 15

Brown pigmentation of iris

Question 15

Ketamine

Answer 15

Disorientation, Hallucinations + Nightmares

Question 15

Levodopa (2)

Answer 15

• Arrhythmias (due to peripheral conversion to dopamine)
• Dyskinesia following admin (seen with long-term use) ;
  Akinesia b/w doses

Question 16

Lithium (2)

Answer 16

• Diabetes Insipidus

- Hypothyroidism (incl Myxedema)

Question 18

Local Anesthetics (-caine) (4)

Answer 18

• CNS excitation
• Arrhythmias (Cocaine)
• Severe CV toxicity (Bupivacaine)
• Hypertension / Hypotension

Question 19

Inhaled Anesthetics (-ane) (5)

Answer 19

• Expansion of trapped gas (NO)
• Proconvulsant (Enflurane)
• Hepatotoxicity (Halothane)
• Nephrotoxicity (Methoxyflurane)
• Malignant Hyperthermia (all EXCEPT N2O)

Question 20

Opioid Analgesics

Pres (4), RX?

** Generally SLOW things down **

Answer 20

PRES: * Tolerance DOESN’T develop to miosis + constipation.*

• Addiction
• CNS + Resp depression (CNS depression additive w other drugs)
• Miosis: “Pinpoint Pupils”
• Constipation

RX:
- Naloxone or Naltrexone (opioid receptor antagonists)

Question 21

Phenobarbital

Answer 21

Rash / Stevens-Johnson Sx

Question 22

Phenytoin (5)

Answer 22

• Nystagmus
• • Gingival Hyperplasia
• Megaloblastic Anemia
• Rash / SLE-like Sx / Stevens-Johnson Sx
• • Hirsutism

Question 23

Reserpine

Answer 23

Parkinson-like Sx

Question 24

Risperidone

Answer 24

Torsades de Pointes / Prolonged QT

Question 25

Selegilline

Answer 25

* Can enhance adverse effects of L-dopa *

Question 26

Sumatriptan (2) CI (2)?

Answer 26

- Coronary vasospasm - Mild tingling CI: patients with CAD or Prinzmetal's Angina

Question 27

Topiramate (2)

Answer 27

- Weight LOSS | - Kidney Stones

Question 28

Tramadol (3)

Answer 28

- Opioid toxicity s+s - Serotonin Sx - Proconvulsant (↓seizure threshold)

Question 29

Valproic Acid (5)

Answer 29

- Tremor - Weight GAIN - GI distress - Hepatic necrosis - Spina Bifida in fetus

Question 30

NON-DEPOLARIZING Neuromuscular Blocking Drugs (-cur-) Reversal of Blockade with?

Answer 30

Anticholinesterases

Question 31

Succinylcholine: DEPOLARIZING Neuromuscular Blocking Drug (2) Reversal of Blockade (Phase II = repol but blocked) with?

Answer 31

- ↑K + Ca - Malignant Hyperthermia Anticholinesterase (eg Neostigmine)

Question 32

Drugs that cause Cinchonism (2)?

Answer 32

- Quinidine | - Quinine (anti-malarial)

Question 33

Drugs that cause Parkinson-like Sx (3)?

Answer 33

- Antipsychotics - Reserpine - Metoclopramide

Question 34

Drugs that cause Red / Green Color-Blindness (2 Antibiotics)?

Answer 34

- Amphoctericin B | - Ethambutol

Question 35

Drugs that cause Retinopathy | (2: 1 Antiprotozoan + 1 Antiviral Class)?

Answer 35

- Chloroquine | - Viral Release Inhibitors (Zanamivir + Oseltamivir)

Question 36

Drug Class that causes Tardive Dyskinesia

Answer 36

Antipsychotics

Question 37

Drug Class that causes Visual Disturbances?

Answer 37

SERMs

Question 38

Drugs that cause Seizures (3: 1 Neuro + 2 Antibiotics)?

Answer 38

- Bupropion - Imipenem / Cilastatin - Isoniazid (INH)

Question 39

Drugs that can cause Serotonin Sx

Answer 39

- Linezolid

Question 40

NEUROTOXIC Drugs Mech, General Pres (6), Drugs (7 Antibiotics)?

Answer 40

MECH = Lipid-soluble drugs => Cross BBB. PRES: - Headaches - Dizziness / Ataxia - Confusion / Mental Status abnormalities - Sensory disturbances (incl vision problems) - Speech problems - Seizures DRUGS: - Carbapenems - Fluoroquinolones - INH - Terbinafine - Griseofulvin - Amantadine - Efavirenz

Question 41

OTOTOXIC Drugs (2 Antibiotics)

Answer 41

- Vancomycin | - Aminoglycosides

Question 42

Drugs that cause Acoustic Nerve Damage

Answer 42

Cis-/Carboplatin

Question 43

Drugs that cause Peripheral Neuropathy

Answer 43

Vincristine