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Flashcards in NEURO Deck (44):
0

Amantadine

Ataxia

1

Alzheimer's Drugs

(4)?

- Dizziness
- Nausea: D, G + R
- Insomnia: D, G + R
- Confusion + Hallucinations: Memantine

2

Antipsychotics (2)

- Parkinson-like Sx
- Tardive dyskinesia

4

Barbiturates

Pres (4), CI?

*** Induces P450 and SLOWS things down. ***

- P450 drug interactions
- Dependence
- Additive CNS depression with alcohol
- CV + Resp depression (can lead to death)

CI in Porphyria.

5

Benzodiazepines (-lam/pam) / Nonbenzo Hypnotics (Z Drugs)

Pres (3), RX for OD?

PRES:
-↓BP
- Severe postop resp depression
- Amnesia
- Ataxia + Confusion + Headaches (Z drugs)

RX for OD = Flumazenil (competitive antagonist at GABA benzo receptor)

6

Brimonidine (3)

- Blurry vision
- Sensation of foreign object in eye
- Ocular hyperemia + pruritus

6

Buproprion

Seizures

8

Carbamazepine (3)

- Blood Dyscrasias (Agranulocytosis + Aplastic Anemia)
- SIADH
- Steven-Johnson Sx

9

DFH (CI: 2 Types of Generalized Seizures)

- Myoclonic seizures
- Absence seizures

10

Clozapine

Agranulocytosis

11

Epilepsy Drugs (General / Common Toxicities) (7)

- Tolerance + Dependence
- Sedation
- Ataxia
- Diplopia
- Steven-Johnson Sx
- Induction of P450 + Liver Toxicity
- Teratogenicity

11

Ethosuximide (3)

- GI distress
- Urticaria
- Steven-Johnson Sx

12

Halothane

Hepatic necrosis

14

Lamotrigine

Steven-Johnson Sx

15

Latanoprost

Brown pigmentation of iris

15

Ketamine

Disorientation, Hallucinations + Nightmares

15

Levodopa (2)

- Arrhythmias (due to peripheral conversion to dopamine)
- Dyskinesia following admin (seen with long-term use) ;
Akinesia b/w doses

16

Lithium (2)

- Diabetes Insipidus
- Hypothyroidism (incl Myxedema)

18

Local Anesthetics (-caine) (4)

- CNS excitation
- Arrhythmias (Cocaine)
- Severe CV toxicity (Bupivacaine)
- Hypertension / Hypotension

19

Inhaled Anesthetics (-ane) (5)

- Expansion of trapped gas (NO)
- Proconvulsant (Enflurane)
- Hepatotoxicity (Halothane)
- Nephrotoxicity (Methoxyflurane)

- Malignant Hyperthermia (all EXCEPT N2O)

20

Opioid Analgesics

Pres (4), RX?

*** Generally SLOW things down ***

PRES: *** Tolerance DOESN'T develop to miosis + constipation.***
- Addiction
- CNS + Resp depression (CNS depression additive w other drugs)
- Miosis: "Pinpoint Pupils"
- Constipation

RX:
- Naloxone or Naltrexone (opioid receptor antagonists)

21

Phenobarbital

Rash / Stevens-Johnson Sx

22

Phenytoin (5)

- Nystagmus
* - Gingival Hyperplasia
- Megaloblastic Anemia
- Rash / SLE-like Sx / Stevens-Johnson Sx
* - Hirsutism

23

Reserpine

Parkinson-like Sx

24

Risperidone

Torsades de Pointes / Prolonged QT

25

Selegilline

* Can enhance adverse effects of L-dopa *

26

Sumatriptan (2)

CI (2)?

- Coronary vasospasm
- Mild tingling

CI: patients with CAD or Prinzmetal's Angina

27

Topiramate (2)

- Weight LOSS
- Kidney Stones

28

Tramadol (3)

- Opioid toxicity s+s
- Serotonin Sx
- Proconvulsant (↓seizure threshold)

29

Valproic Acid (5)

- Tremor
- Weight GAIN
- GI distress
- Hepatic necrosis

- Spina Bifida in fetus

30

NON-DEPOLARIZING Neuromuscular Blocking Drugs (-cur-)

Reversal of Blockade with?

Anticholinesterases

31

Succinylcholine: DEPOLARIZING Neuromuscular Blocking Drug (2)

Reversal of Blockade (Phase II = repol but blocked) with?

- ↑K + Ca
- Malignant Hyperthermia

Anticholinesterase (eg Neostigmine)

32

Drugs that cause Cinchonism (2)?

- Quinidine
- Quinine (anti-malarial)

33

Drugs that cause Parkinson-like Sx (3)?

- Antipsychotics
- Reserpine
- Metoclopramide

34

Drugs that cause Red / Green Color-Blindness (2 Antibiotics)?

- Amphoctericin B
- Ethambutol

35

Drugs that cause Retinopathy
(2: 1 Antiprotozoan + 1 Antiviral Class)?

- Chloroquine
- Viral Release Inhibitors (Zanamivir + Oseltamivir)

36

Drug Class that causes Tardive Dyskinesia

Antipsychotics

37

Drug Class that causes Visual Disturbances?

SERMs

38

Drugs that cause Seizures (3: 1 Neuro + 2 Antibiotics)?

- Bupropion
- Imipenem / Cilastatin
- Isoniazid (INH)

39

Drugs that can cause Serotonin Sx

- Linezolid

40

NEUROTOXIC Drugs

Mech, General Pres (6), Drugs (7 Antibiotics)?

MECH = Lipid-soluble drugs => Cross BBB.

PRES:
- Headaches
- Dizziness / Ataxia
- Confusion / Mental Status abnormalities
- Sensory disturbances (incl vision problems)
- Speech problems
- Seizures

DRUGS:
- Carbapenems
- Fluoroquinolones
- INH
- Terbinafine
- Griseofulvin
- Amantadine
- Efavirenz

41

OTOTOXIC Drugs (2 Antibiotics)

- Vancomycin
- Aminoglycosides

42

Drugs that cause Acoustic Nerve Damage

Cis-/Carboplatin

43

Drugs that cause Peripheral Neuropathy

Vincristine