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Flashcards in General Deck (22):
0

Noncompetitive Inhibitors

Mech of Action (2)?

MECH:
- Bind Irreversibly to receptor = Bind to receptor's Allosteric Site
- ↓Potency =↓Vmax

1

Competitive Inhibitors

Mech of Action (3)?

MECH:
- Bind REVERSIBLY to receptor = Bind to receptor's Active Site
- ↓receptor's Affinity for substrate =>↑Km
- Can be overcome by↑substrate

2

Drugs that can Cross Barriers (ie BBB, BPB)

Chars (3), Toxicities (3)?

CHARS:
- Uncharged =
- Hydrophobic / Lipophilic
- Basic (usually)

TOX:
- Hepatotoxicity
- CNS symptoms
- Rhabdomyolysis

3

Metabolized by P450

- RESP Drugs: Methylxanthines (ie Theophylline)

4

P450 Inducers (7)

* "Barb Steals Phen and Refuses Greasy Carbs Chronically" *

- Barbiturates
- St John's Wort
- Phenytoin
- Rifampin
- Griseofulvin
- Carbamazepine
- Chronic alcohol abuse

5

P450 Inhibitors (11)

* "MAGIC RACKS" *

- Macrolides
- Amiodarone
- Grapefruit juice
- Isoniazid
- Cimetidine
- Ritonavir
- Acute alcohol abuse
- Ciprofloxacin
- Ketoconazole (and other -azoles)
- Sulfonamides
- Quinidine

6

Sulfa Drugs (9)

Sulfa Allergy Pres (5)?

* "Popular FACTSSS" *

- Probenacid
- Furosemide
- Acetazolamide
- Celecoxib
- Thiazides
- Sulfonamide antibiotics
- Sulfasalazine
- Sulfonylureas
- Dapsone (for Leprosy)

PRES:
- Cytopenia
- Fever
- Hives / Pruritic rash
- Stevens-Johnson Sx
- UTIs

7

Nitro + Sulfa Drugs

Mech of Action, Mech of Toxicity (2)?

MECH: Oxidizing agents

TOX (MECH):
- Production of Methemoglobin
- Production of Hemolysis in G6PD Deficiency
(↑in peroxide destroys RBCs)

8

Electron Transport Inhibitors (4)

Mech?

MECH: Inhib e transport ->↓proton gradient.

- CO
- Cyanide
- Antimycin A
- Rotenone

9

ATP Synthase Inhibitor

Mech?

MECH: Inhib ATP Synthase -> Inhib e transport ->↑proton gradient.

- Oligomycin

10

Uncoupling Agents (3)

Mech, Pres (2)?

MECH:↑memb permeability -> ↓proton gradient.
*E transport continues
*↑O2 consumption = Heat production + Hypoxia

PRES:
- Hypoxia
- Hyperthermia

- Alcohol
- Aspirin
- 2,4- Dinitrophenol (used illicitly for weight loss)

11

Erythema Multiforme -> Stevens-Johnson Sx ->
Toxic Epidermal Necrolysis

Causative Drugs (8: 2 Antibiotic Classes, 5 Epilepsy, 1 Gout)?

- Penicillins
- Sulfa Drugs

- Phenobarbital
- Phenytoin
- Carbamazepine
- Ethosuximide
- Lamotrigine

- Allopurinol

12

Arthus Rx

Mech, Pres (2)?

MECH: Type 3 HS- antigen-ab complexes form in skin.

PRES: After intradermal injection of antigen (eg Tetanus vaccine)
- Infl / Edema
- Necrosis

13

Jarisch-Herxheimer Rx

Mech, Pres?

MECH = Killed bacteria releasing pyrogens / toxins.

PRES = Flu-like sx after antibiotics (usually for Syphilis) started

14

Restrictive Lung Disease

Causative Drugs (4)?

- Amiodarone
- Bleomycin
- Busulfan
- Methotrexate

15

Reactions to Transfusion

- DIC

16

Disulfiram-like Effects

Def'n, Mech (3 steps), Causative Drugs / Drug Classes (3)?

(Antabuse). Hypotension, flushing + sweating, severe headache, nausea + vomiting.

MECH:
Inhib of Aldehyde dehydrogenase ->
Alcohol can't be metabolized ->
↑in Aldehyde.

DRUGS:
- 1st Generation Sulfonylureas
- Cephalosporins
- Metronidazole

17

Lead Poisoning

Sign?

'Burton Line': Bluish line on gingiva

18

a-amanitin (in Amanita phalloides = "Death Cap mushrooms")

Mech, Toxicity?

MECH = Inhib of RNA Polymerase II

TOX = Severe Hepatotoxicity

19

Arsenic Toxicity

Mech, Pres (3)?

MECH = Inhib of Lipoic acid (cofactor in Pyruvate Dehydrogenase complex).

PRES:
- Garlic breath
- Vomiting
- Rice-Water stools

20

Arsenic Exposure

Comp?

COMP:
- Squamous Cell Carcinoma

21

Drugs Contraindicated in Pregnancy

- Antibiotics (10: 6 antibiotics + 1 antifungal + 3 antivirals)
- Thyroid Drug
- Cancer Drug (Antimetabolite)
- CV / Renal Drug Class

- Sulfonamides -> Kernicterus
- Fluoroquinolones (-floxacin / oxacin) -> cartilage damage
- Aminoglycosides (-mycin) + Tetracyclines (-cycline)
- Macrolides (-thromycin)
- Chloramphenicol -> Gray Baby Sx
- Metronidazole -> Mutagenesis
- Griseofulvin
- Ribavirin
- Delavirdine + Efavirenz

- Methimazole

- MTX

- ACE Inhibitors