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Flashcards in ONC Deck (16):
0

Cancer Drugs ~GENERAL~

(S/E profile of most cancer drugs: 4)?

*** BM, Skin, Hair, GI ***

1

Bleomycin + Busulfan

Pulmonary Fibrosis

*** Also Hyperpigmentation + SEVERE myelosuppression w Busulfan ***

2

Cisplatin

Nephrotoxicity / Ototoxicity

3

Cyclophosphamide (3)

- SIADH
- Hemorrhagic Cystitis
- Bladder Ca

4

Dauno- + Doxorubicin

Dilated Cardiomyopathy

5

Hydroxyurea

GI upset

6

Ifosfamide

Hemorrhagic Cystitis
* Prevent by co-administering MESNA *

7

Methotrexate

(2)?

- Megaloblastic Anemia with hypersegmented neutrophils
- Interstitial fibrosis in Lungs

7

Imatinib

Fluid retention

9

Procarbazine

Disulfiram-like rx

9

Prednisone / Prednisolone

Cushing-like s+s

10

Nitrosoureas: -stine + Streptozocin

CNS toxicity

10

Vemurafenib

Metastatic Melanoma

12

Alkylating Chemotherapy

AML

13

6-MPT

Metab, CI?

METAB = by Xanthine Oxidase.

CI:
- Allopurinol (inhibits XO)

15

Radiation Therapy

AML