Endocrine Flashcards
What is the feedback of Oestrogen to LH and FSH
In moderate levels it will negatively feedback
In high levels it will positively feedback
In the presence of progesterone it will negatively feed back
Describe the HPA axis
Stress stimulates the hypothalamus to send corticotrophin releasing hormone to Ant. Pituitary
Ant. pituitary sense adrenocorticotrophic hormone (ACTH) to adrenal gland
Cortisol is produced in the Zona Fasciculata
Cortisol negatively feeds back to rest of HPA axis
What are the functions of cortisol
Gluconeogenesis Carb metabolism Reduced inflammation Proteolysis Lipolysis Reduced bone formation
What is the HPS axis
Hypothalamic–pituitary–somatotropic axis
GHRH > GH > effects e.g insulin like growth factor
Antagonized by hypothalamus somatostatin release
HPT axis function
Thyrotropin Releasing Hormone > Thyroid stimulating hormone > T3/T4
TRH >TSH > T3/T4
What does the act of suckling stimulate
Release of Prolactin and TRH
What inhibits the release of prolactin
Dopamine
what is the role of posterior pituitary Oxytocin
Acts on breasts to allow milk to move through the lactiferous ducts
Uterine contractions during labour due to cervical stretch
Oxytocin has a positive feedback with itself
what causes the release of ADH
Osmoreceptors in the hypothalamus
What is the main action of insulin
Movement of Glut4 channels to the cell surface
what receptor aids facilitated diffusion of glucose in the pancreas
GLUT2
What is the general action of T3 and T4 released from the thyroid
Increase in Basal Metabolic Rate
What effect for T3 have on the brain
Important for development
- axon terminals
- synapses
- dendritic growth
- Myelination
What effect does T3 have on metabolism
Increase carb absorption in SI
Increased FA release from adipocytes
Increase BMR and Body temp
What are the layers of the Epidermis
Stratum Corneum Stratum Lucidum Stratum Granulosum Stratum Spinosum Stratum Basale
Come, Let’s Get Sun Burned
