Renal Flashcards
Where does gluconeogenesis occur?
Kidney
where is erythropoietin produced
interstitial fibroblasts of the kidney
What are the 3 layers of the bowmen’s capsule
Fenestrated capillaries
Basement membrane - type 4 collagen
Podocyte foot processes
give the glomerular filtration rate ratios
20% of blood flow is to kidneys - 5*.2= 1L/min
60% of blood is plasma - 600ml
20% of plasma is filtered - 120ml/min
what substance is used to estimate GFR?
Creatinine - freely filtered but not secreted or reabsorbed
How can you calculate clearance
plasma concentration
what is renal clearance
the volume of plasma required to pass through the kidney to remove a substance per unit time
Where does the bulk of glucose, sodium, Chloride, lactate, amino acids, water, and bicarb reabsorption occur
Proximal tubule
what is the longest segment of the renal tubule?
proximal tubule
What is the Macula Densa
Proximal part of the distal tubule that detects Na+ concentration
Paracrine stimulation of juxtaglomerular cells to release renin
Effects the afferent arteriole
The macula dense detects low sodium levels, what is the response
Low sodium concentration means blood pressure and GFR is low
- Dilation of afferent arteriole - More filtration
- Release of Renin - Sodium and water reabsorption
Action of ADH/vasopressin
Aquaporin insertion into Collecting Ducts - water absorption
action of Aldosterone
Insertion of sodium transporters to the distal tubule and collecting ducts to increase sodium reabsorption
What is the function of intercalated cells of the kidney
Secretes acid for acid/base homeostasis
what is the kidney’s response to acidosis
Produces new HCO3-
Decreases excretion of HCO3-
