Endocrine Pathology Flashcards Preview

RUSVM Pathology II > Endocrine Pathology > Flashcards

Flashcards in Endocrine Pathology Deck (88)
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1

Kids that were born dead or died shortly after birth, weak with large neck "masses" some were hairless.  What endocrine disorder would be at the top of your DDx?

Goiter

2

Characteristic lesions associated with Diabetes Mellitus

Cataracts (Dogs Only)

Microangiopathy

Hepatic Lipidosis

Lesions caused by infections

3

(Primary/Secondary) endocrine disorders involve decreased cellular activity or increased cellular activity of the endocrine gland.

Primary Endocrine Disorders

4

Endocrine function of goiter

Euthyroid or Hypothyroid

5

Endocrine function of Diabetes Mellitus

Hypoinsulinemia

6

Pathogenesis of Diabetic Nephropathy

  1. Chronic hyperglycemia
  2. Formation of glycosylated proteins
  3. Deposition into caplillary basement membranes
  4. Thickened basement membrane ("microangiopathy)

7

Pancreas: Morphological Diagnosis

Chronic Pancreatitis

8

Morphological Diagnosis

Thyroid Hyperplasia

9

Histological Appearance of

Adrenocortical Neoplasm

10

(Primary/Secondary) Endocrine disorders consist of a lesion of another organ that leads to decreased or increased cellular activity of the endocrine gland

Secondary Endocrine Disorder

11

Hypopituitarism causes what endocrine disorder?

Hypoadrenocortisim - Addison's Disease

12

Cause of Primary Hyperparathyroidism

PTH producing Parathyroid Neoplasm

13

Insulin resistance can occur secondary to

Hyperadrenocorticism

Obesity

Pregnancy

14

Pathogenesis of cataracts due to DM

Excessive glucose taken up by epithelium of the lens →  metabolized to sorbitol by aldose reductase →  sorbitol osmotically draws water into the lens →  cataract formation

15

Morphological Diagnosis

Adrenocortical Adenoma/Carcinoma

_____________________

Require histology to differentiate

16

Pathogenesis of Islet Cell Vacuolar Degeneration

  1. Insulin Resistance
  2. Long term overstimulation of Beta-Cells
  3. Intracellular accumulation of glycogen
  4. Vacuolar degeneration of beta cells
  5. Insulin deficiency and more severe diabetes mellitus

17

Endocrine disorder that causes hypertension and polymopathy (due to hypernatriemia and hypokalemia)

Hyperaldosteronism - Conn's Syndrome

18

What dis?

Pheochromocytoma

__________________________

Would need to be differentiated from Adrenocortical Neoplasm with histopathology

19

Lesion assoicated with what endocrine disorder?

Steroid Hepatopathy

Hyperadrenocorticism - Cushing's Disease

20

Histology of a pancreas from a cat with Diabetes mellitus due to:

Insulin Antagonism

21

In horses, most pituitary adenomas are from where, and some produce ACTH.

Pars intermedia

22

Lesions that may be associated with Hyperadrenocorticism

Adrenocortical Adenoma/Carcinoma

Steroid Hepatopathy

Calcinosis cutis

Pituitary Adenoma

23

Endocrine disease that causes nodular thyroid hyperplasia. Characterized by increased appetite with weight loss, PU, enlarged nodular thyroids and histologically abnormal follicles.

Hyperthyroidism

24

Histologic appearance of lesion associated with what endocrine disease?

Calcinosis cutis

Hyperadrenocorticism - Cushings Disease

25

Histologic appearance of what lesion associated with what endocrine disease?

Steroid Hepatopathy

Hyperadrenocorticism - Cushing's Disease

26

Possible causes of hyperadrenocorticism

Adrenocortical adenoma/ carcinoma

ACTH secreting pituitary adenoma

Adrenocortical hyperplasia

Iatrogenic

27

Thyroid carcinomas can arise from what types of cells

Follicular Cells

C Cells

28

Why might you see this lesion with secondary hyperparathyroidism?

PTH stimulates increased resorption of bone

Chronic PTH stimulates bone marrow stromal cells to differentiate into fibroblasts

High P and low vitamin D > Low Ca > inability to properly mineralize growing bown due to low Ca and uremic acidosis

29

Morphological Diagnosis

Nodular Thyroid Hyperplasia

30

Endocrine function of thyroid carcinomas

Euthyroid