Hematopoietic System Pathology Flashcards Preview

RUSVM Pathology II > Hematopoietic System Pathology > Flashcards

Flashcards in Hematopoietic System Pathology Deck (126):
1

Morphological diagnosis

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Acute multifocal necrotizing hepatitis and splenitis

2

Splenomegaly caused by 

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Amyloidosis

3

Indications for examining bone marrow

Unexplained cytopenia

Maturation defects or morphologic abnormalities in blood cells

Potential myelo/lympho-proliferative disease

Potential malignancies

4

Condition

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Splenic Hemangioma

5

Etiology of Strangles

Streptococcus equi subsp equi

6

Condition

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Multiple "Spleens"

7

Autosomal recessive bone marrow disorder that disrupts the sequence of steps leading to the migration of leukocytes into sites of inflammation leading to bone marrow hyperplasia

Bovine Leukocyte Adhesion Deficiency Syndrome - BLAD

8

Differential diagnosis for hyperplastic splenitis

Aleutian Disease

Equine Infectious Anemia

9

Differential diagnosis for splenic thrombosis/ infarction

Classicial Swine Fever (Hog Cholera)

Lymphosarcoma

10

Splenic nodules with a blood consistency can be

Hematomas

Incompletely contracted areas of spleen

Acute splenic infarcts

Vascular neoplasms

11

Bloody spleen can be generally caused by

Congestion

Acute Hyperemia

Acute Hemolytic Anemia

12

Disease in pigs that causes diffuse granulomatous lymphadenitis

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Postweaning Multisystemic Wasting Disease

13

Morphological Diagnosis

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Necrotizing splenitis

14

Malignant bone marrow neoplasm of histiocytic origin.

Histocytic Sarcoma

15

Disease in which carbon particles are retained in macrophages, medulla of lymph node appears black.

Anthracosis

________________________________

Common finding in animals living in polluted urban areas

16

Disease of the spleen that causes necrotizing splenitis characterized by white-grey milliary foci scarttered throughout the splenic parenchyma.

Tularemia - Rabbit Fever

17

Condition

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Histiocytic Sarcoma

18

Hemal Nodes

Prominant in ruminants, small, dark red similar architecture

19

Bone Marrow Hypoplasia/ Atrophy may be the result of 

Myelophthisis

Abnormality of hematopoietic cells

20

Etiology of Cytauxzoonosis

Cytauxzoon felis

21

Disease

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Multiple Myeloma

22

Condition

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Splenic hemangiosarcoma

23

Etiology

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Histoplasma capsulatum

24

Disease that causes granulomatous lymphadenitis characterized by B and T lymphoid depletion and "botryoid" intracytoplasmic inclusions in macrophages.

Post Weaning Multisystemic Wasting Disease - PMWD

25

Etiology of granulomatous splenitis

Mycobacterium avium

26

Etiologic Agent and Disease

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Francisella tularensis

Tularemia

27

Disease of the raptors characterized by acute multifocal milliary necrotizing hepatitis and splenitis.

Herpes Inclusio Body Disease - Hepatosplenitis

28

Splenic infarction in pigs is an indication of what disease

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Classical Swine Fever - Hog Cholera

29

Disease caused by the organism in these tissue aspirates of the lymph node and spleen of a cat

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Cytauxzoonosis

30

Dogs with benign splenic masses had a significantly (higher/lower) mean to splenic volume ration and (higher/lower) splenic weight as a percentage of body weight than did dogs with hemangiosarcoma.

Dogs with benign splenic masses had a significantly (higher/lower) mean to splenic volume ration and (higher/lower) splenic weight as a percentage of body weight than did dogs with hemangiosarcoma.

31

Lesion associated with this lymph node asipirate

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Granulomatous Lymphadenitis

32

Splenomegaly due to diffuse enlargement can be due to

Congestion

Cell proliferation/ infiltration

Accumulation of extracellular material

33

Lesion

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Granulomatous Lymphadenitis

34

Disease characterized by mandibular, pharyngeal, parotid lymph node abscesation and fistulization

Strangles

35

Morphological Diagnosis

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Bone Marrow Hyperplasia

36

Disease of 3-6 week old chicks that causes lymphoid depletion by targeting pre-B lymphocytes

Infectious Bursal Disease (IBD)

37

Disease of the spleen characterized by grey-white to yellow, hard dry encrustations on the capsule, usually along the margins of teh spleen but can be elsewhere.

Siderofibrosis

38

Disease of equids characterized by abscesses anywhere in the body other than the pharyngeal area

Bastard Strangles

39

Condition

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Splenic Hematoma

40

Lymph node abscess in a horse what is the etiology?

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Streptococcus equi subsp equi

41

Pathogenesis of Bone Marrow Hyperplasia

Increased cell production in the marrow in response to poietins and interleukins → decreased cell numbers in blood caused by increased peripheral demand → adequate numbers of hypofunctional cells in peripheral blood

42

Etiology of Anthrax

Bacillus anthracis

43

Bone marrow necrosis may result in what clinical pathology finding?

Pancytopenia

44

Lesions associated with what disease of chickens?

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Marek's Disease

45

Abnormality

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None - normal active bone marrow

46

Disease characterized by increased yellow marrow and is usually accompanied by marrow degeneration.  Clinical pathology findings include anemia, neutropenia, thrombocytopenia.

Bone Marrow Hypoplasia / Atrophy

47

Differential Diagnosis for hemosiderosis of the spleen

Decreased rate of erythropoiesis

Rapid destruction of RBC

Chronic heart failure

Iron dextran injection

48

Brownish discoloration observed in lymph nodes draining areas of hemorrhage

Hemosiderosis

49

Etiology of Caseous Lymphadenitis

Corynebacterium pseudotuberculosis

50

Condition

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Lymphoid Hyperplasia

51

(Cutaneous / Extramedullary) Plasmacytomas are typically malignant

Extramedullary Plasmacytomas

52

Disease

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Multiple Myeloma

53

Etiology of Infectious Bursal Disease (IBD)

Avian Bursal Disease Virus

54

Condition

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Thymic Lymphosarcoma

55

Disease of the spleen that causes acute splenitis.  It is characterized by acute death, bloated carcass, rapid-post mortem autolysis and blood oozing from body orifices.

Anthrax

56

Likely etiology of suppurative osteomyelitis

Bacterial infection

57

Differential Diagnosis for focal areas of necrosis in lymph node

Yersina Pestis

Toxoplasmosis

Salmonellosis

Tularemia

Tyzzer's Disease

Feline Infectious Peritonitis

58

Disease of the bone marrow that is often fatal due to occulusion of lumina of vessles in the lung, brain, liver, lymph node and spleen.

Cytauxzoonosis

59

Etiology of Tularemia

Francisella tularensis

60

Normal Myeloid: Erythroid Ratio

1.5 : 1

61

What should you evaluate on a core biopsy of bone marrow

Cellularity

Myeloid: Erythroid Ratio

62

Disease and Etiology

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Granulomatous Splenitis

Mycobacterium avium

63

Etiology of bubonic plague

Yersinia pestis

64

Possible causes of bone marrow hyperplasia

Bovine Leukocyte Adhesion Deficiency Syndrome - BLAD

IHA

Equine Infectious Anemia

65

Spleen of a cow that acutely died and was found bloated what is the most likely disease?

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Anthrax

66

Disease

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Bone Marrow Lymphoma

67

Condition

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Splenic Lymphosarcoma

68

Condition

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Thymic Lymphoma

69

Common features of myelo/lympho-proliferative disease

Anemia

Hypercellular Marrow

Leukemic Cells in peripheral circulation

Megaloblastic alteration in erythroid cells

Thrombocytopenia

Hepato/Spleno-megaly

70

During gestation, hematopoietic cells originate in the 

Liver, Spleen and Bone Marrow

71

Disease of 2-5 month old chickens characterized by lymphocytic infiltrates and peripheral neuritis.

Marek's Disease

72

Condition

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Splenic Hemangiosarcoma

73

Etiology of Herpes Inclusion Body Disease

Columbid Herpesvirus 1 (CoHV-1)

74

Condition

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Thymoma

75

Differential Diagnosis for Acute Passive Congestion of the spleen

Barbiturate induced

Equine Infectious Anemia

Gastrosplenic Torsion/ Volvulus

76

Malignant tumor of plasma cells that secretes Ig/Ig subunit.  It is characterized by increased numbers of plasma cells in BM, monoclonal gammopathy, osteolysis, light chain proteinuria, hypercalcemia, cytopenias, and renal amyloidosis.

Multiple Myeloma

77

Disease characterized by painful, swollen lymph nodes with focal areas of necrosis.

Bubonic Plague

78

Meat spleen can be generally caused by

Phagocytosis

Proliferation of Cells

Storage of material

79

Disease of equines that is characterized by immune mediated hemolysis and decreased erythropoeisis leading to bone marrow hyperplasia

Equine Infectious Anemia

80

Primary neoplasias of the bone marrow are divided into

Lymphoproliferative Disorders

Myeloproliferative Disorders

81

Condition

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Splenosis

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Splenic rupture lead to seeding of the omentum and formation of numerous "accessory spleens"

82

Splenic nodules with a firm consistency could be

Splenic nodular hyperplasia

Fibrohistiocytic nodules

Primary neoplasms

Secondary neoplasms

Granulomas

Abscesses

83

Etiology

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Bovine Enzootic Leukosis

84

Degenerative lesion of the spleen

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Siderofibrosis

85

Likely etiology of granulomatious osteomyelitis

Fungal infection

86

Splenic rupture leading to seeding of the omentum and formation of numerous accessory spleens

Splenosis - Splenic Rupture

87

Differential diagosis for thymic atrophy

EHV 1

FeLV

Feline Panleukemia

BVD

Canine Distemper

88

Disease of chickens that is characterized by the proliferation of B lymphocytes.

Lymphoid Leukosis

89

Possible DDX

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Multiple Myeloma

Osteomyelitis

90

Disease

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Lymphosarcoma

91

Etiology

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Corynebacterium pseudotuberculosis

92

Replacement of myeloid tissue by abnormal tissue

Myelophthisis

93

(Lympho/Myelo)-proliferative diseases are more common.

Lymphoproliferative Diseases

94

Disease characterized by greenish coored pus that becomes caseous with age.

Caseous Lymphadenitis

95

Etiology of Marek's Disease

Herpesvirus

96

Two common locations for hemangiosarcomas

Subcutis 

Right Atrium

 

97

Disease

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Caseous Lymphadenitis

98

Condition

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Nodular Hyperplasia

99

Common disease that causes Myelophthisis

Scurvy - Vitamin C Deficiency

100

Differential Diagnosis for thymic hypoplasia

Severe Combined Immunodeficiency (SCID)

X- Linked Gene

101

Describe the appearance of porcine lymph nodes

Inverted cortex and medulla

102

Disease

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Serous Atrophy of Fat

103

Rare neoplasm of the bone marrow that is usually benign and of the skin or mucous membrane origin.

Cutaneous Plasmocytoma

104

Non neoplastic canine immunoregulatory disorders

Cutaneous Histocytosis

Systemic Histocytosis

105

Condition

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Histiocytic Sarcoma

106

Disease of the spleen caused by chronic antigenic stimulation leading to hyperplasia of the monocyte-macrophage or lymphoid/plasma cell population

Hyperplastic splenitis

107

Etiology

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Mycobacterium bovis

108

Disease

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Suppurative Osteomyelitis

109

Lesion

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Myelofibrosis

___________________

Can be caused by Scurvy in guinea pigs

110

In the embryo, hematopoietic cells originate in the

Yolk Sac

111

Differential diagnosis for granulomatous lymphadenitis

Mycobacterium bovis

Histoplasma capsulatum

Post weaning Multisystemic Wasting Disease

112

Disease characterized by hyperplastic cell lines (one or multiple) and red marrow replacement by yellow marrow.

Bone Marrow Hyperplasia

113

Pathogenesis of Cytauxzoonosis

Schizogenous phase → Macrophages = Systemic Illness

Erythrocytic phase = Anemia

114

Etiology of Lymphoid leukosis in chickens

Avian Leukosis Virus

115

Bone marrow disease characterized by ineffective and dysplastic hematopoiesis.  Diagnosed based on presence of decreased blasts in bone marrow ( < 30%), cytopenia of > 1 cell line and evidence of dyshematopoiesis.

Myelodysplastic Syndrome (MDS)

116

Release of immature cells from the bone marrow indicates

Stress or disease

117

The bursa of fabricius is populated by what type of lymphocytes

B lymphocytes

118

Main components of the hematopoietic system

Bone marrow

Blood cells

Lymph nodes and lymphatics

Spleen

Mucosa Associated Lymphoid Tissue (MALT)

Thymus

119

Clinical pathology associated with Splenic Hemangiosarcomas

Anemia

Thrombocytopenia

Increased hepatic enzymes

Schistocytes

120

Differential diagnosis for nodular hyperplasia

Lymphoma

Granulomatous infection

121

Histologic lesion associated with pigs infected with PMWS

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"Botryoid" Intracytoplasmic Inclusions in Macrophages

122

Primary neoplasia of the lymphnode characterized by mottled pale tane and red appearance that is slightly buldging and nodular.

Lymphosarcoma

123

Disease and etiology

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Herpes inclusion body disease 

Columbid herpesvirus 1 (CoHV-1)

124

Etiology

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Bacillus anthracis

125

Indolent cutaneous neoplasm of bone marrow.  Probably of dendritic cell origin

Feline Progressive Histiocytosis

126

Splenomegaly caused by

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Barbiturate euthanasia