Hematopoietic System Pathology Flashcards
(126 cards)
1
Q
Morphological diagnosis
A
Acute multifocal necrotizing hepatitis and splenitis
2
Q
Splenomegaly caused by
A
Amyloidosis
3
Q
Indications for examining bone marrow
A
Unexplained cytopenia
Maturation defects or morphologic abnormalities in blood cells
Potential myelo/lympho-proliferative disease
Potential malignancies
4
Q
Condition
A
Splenic Hemangioma
5
Q
Etiology of Strangles
A
Streptococcus equi subsp equi
6
Q
Condition
A
Multiple “Spleens”
7
Q
Autosomal recessive bone marrow disorder that disrupts the sequence of steps leading to the migration of leukocytes into sites of inflammation leading to bone marrow hyperplasia
A
Bovine Leukocyte Adhesion Deficiency Syndrome - BLAD
8
Q
Differential diagnosis for hyperplastic splenitis
A
Aleutian Disease
Equine Infectious Anemia
9
Q
Differential diagnosis for splenic thrombosis/ infarction
A
Classicial Swine Fever (Hog Cholera)
Lymphosarcoma
10
Q
Splenic nodules with a blood consistency can be
A
Hematomas
Incompletely contracted areas of spleen
Acute splenic infarcts
Vascular neoplasms
11
Q
Bloody spleen can be generally caused by
A
Congestion
Acute Hyperemia
Acute Hemolytic Anemia
12
Q
Disease in pigs that causes diffuse granulomatous lymphadenitis
A
Postweaning Multisystemic Wasting Disease
13
Q
Morphological Diagnosis
A
Necrotizing splenitis
14
Q
Malignant bone marrow neoplasm of histiocytic origin.
A
Histocytic Sarcoma
15
Q
Disease in which carbon particles are retained in macrophages, medulla of lymph node appears black.
A
Anthracosis
________________________________
Common finding in animals living in polluted urban areas
16
Q
Disease of the spleen that causes necrotizing splenitis characterized by white-grey milliary foci scarttered throughout the splenic parenchyma.
A
Tularemia - Rabbit Fever
17
Q
Condition
A
Histiocytic Sarcoma
18
Q
Hemal Nodes
A
Prominant in ruminants, small, dark red similar architecture
19
Q
Bone Marrow Hypoplasia/ Atrophy may be the result of
A
Myelophthisis
Abnormality of hematopoietic cells
20
Q
Etiology of Cytauxzoonosis
A
Cytauxzoon felis
21
Q
Disease
A
Multiple Myeloma
22
Q
Condition
A
Splenic hemangiosarcoma
23
Q
Etiology
A
Histoplasma capsulatum
24
Q
Disease that causes granulomatous lymphadenitis characterized by B and T lymphoid depletion and “botryoid” intracytoplasmic inclusions in macrophages.
A
Post Weaning Multisystemic Wasting Disease - PMWD
25
Etiology of granulomatous splenitis
Mycobacterium avium
26
Etiologic Agent and Disease
Francisella tularensis
Tularemia
27
Disease of the raptors characterized by acute multifocal milliary necrotizing hepatitis and splenitis.
Herpes Inclusio Body Disease - Hepatosplenitis
28
Splenic infarction in pigs is an indication of what disease
Classical Swine Fever - Hog Cholera
29
Disease caused by the organism in these tissue aspirates of the lymph node and spleen of a cat
Cytauxzoonosis
30
Dogs with benign splenic masses had a significantly (higher/lower) mean to splenic volume ration and (higher/lower) splenic weight as a percentage of body weight than did dogs with hemangiosarcoma.
Dogs with benign splenic masses had a significantly (**higher**/lower) mean to splenic volume ration and (**higher**/lower) splenic weight as a percentage of body weight than did dogs with hemangiosarcoma.
31
Lesion associated with this lymph node asipirate
Granulomatous Lymphadenitis
32
Splenomegaly due to diffuse enlargement can be due to
Congestion
Cell proliferation/ infiltration
Accumulation of extracellular material
33
Lesion
Granulomatous Lymphadenitis
34
Disease characterized by mandibular, pharyngeal, parotid lymph node abscesation and fistulization
Strangles
35
Morphological Diagnosis
Bone Marrow Hyperplasia
36
Disease of 3-6 week old chicks that causes lymphoid depletion by targeting pre-B lymphocytes
Infectious Bursal Disease (IBD)
37
Disease of the spleen characterized by grey-white to yellow, hard dry encrustations on the capsule, usually along the margins of teh spleen but can be elsewhere.
Siderofibrosis
38
Disease of equids characterized by abscesses anywhere in the body other than the pharyngeal area
Bastard Strangles
39
Condition
Splenic Hematoma
40
Lymph node abscess in a horse what is the etiology?
Streptococcus equi subsp equi
41
Pathogenesis of Bone Marrow Hyperplasia
Increased cell production in the marrow in response to poietins and interleukins → decreased cell numbers in blood caused by increased peripheral demand → adequate numbers of hypofunctional cells in peripheral blood
42
Etiology of Anthrax
Bacillus anthracis
43
Bone marrow necrosis may result in what clinical pathology finding?
Pancytopenia
44
Lesions associated with what disease of chickens?
Marek's Disease
45
Abnormality
None - normal active bone marrow
46
Disease characterized by increased yellow marrow and is usually accompanied by marrow degeneration. Clinical pathology findings include anemia, neutropenia, thrombocytopenia.
Bone Marrow Hypoplasia / Atrophy
47
Differential Diagnosis for hemosiderosis of the spleen
Decreased rate of erythropoiesis
Rapid destruction of RBC
Chronic heart failure
Iron dextran injection
48
Brownish discoloration observed in lymph nodes draining areas of hemorrhage
Hemosiderosis
49
Etiology of Caseous Lymphadenitis
Corynebacterium pseudotuberculosis
50
Condition
Lymphoid Hyperplasia
51
(Cutaneous / Extramedullary) Plasmacytomas are typically malignant
Extramedullary Plasmacytomas
52
Disease
Multiple Myeloma
53
Etiology of Infectious Bursal Disease (IBD)
Avian Bursal Disease Virus
54
Condition
Thymic Lymphosarcoma
55
Disease of the spleen that causes acute splenitis. It is characterized by acute death, bloated carcass, rapid-post mortem autolysis and blood oozing from body orifices.
Anthrax
56
Likely etiology of suppurative osteomyelitis
Bacterial infection
57
Differential Diagnosis for focal areas of necrosis in lymph node
Yersina Pestis
Toxoplasmosis
Salmonellosis
Tularemia
Tyzzer's Disease
Feline Infectious Peritonitis
58
Disease of the bone marrow that is often fatal due to occulusion of lumina of vessles in the lung, brain, liver, lymph node and spleen.
Cytauxzoonosis
59
Etiology of Tularemia
Francisella tularensis
60
Normal Myeloid: Erythroid Ratio
1.5 : 1
61
What should you evaluate on a core biopsy of bone marrow
Cellularity
Myeloid: Erythroid Ratio
62
Disease and Etiology
Granulomatous Splenitis
Mycobacterium avium
63
Etiology of bubonic plague
Yersinia pestis
64
Possible causes of bone marrow hyperplasia
Bovine Leukocyte Adhesion Deficiency Syndrome - BLAD
IHA
Equine Infectious Anemia
65
Spleen of a cow that acutely died and was found bloated what is the most likely disease?
Anthrax
66
Disease
Bone Marrow Lymphoma
67
Condition
Splenic Lymphosarcoma
68
Condition
Thymic Lymphoma
69
Common features of myelo/lympho-proliferative disease
Anemia
Hypercellular Marrow
Leukemic Cells in peripheral circulation
Megaloblastic alteration in erythroid cells
Thrombocytopenia
Hepato/Spleno-megaly
70
During gestation, hematopoietic cells originate in the
Liver, Spleen and Bone Marrow
71
Disease of 2-5 month old chickens characterized by lymphocytic infiltrates and peripheral neuritis.
Marek's Disease
72
Condition
Splenic Hemangiosarcoma
73
Etiology of Herpes Inclusion Body Disease
Columbid Herpesvirus 1 (CoHV-1)
74
Condition
Thymoma
75
Differential Diagnosis for Acute Passive Congestion of the spleen
Barbiturate induced
Equine Infectious Anemia
Gastrosplenic Torsion/ Volvulus
76
Malignant tumor of plasma cells that secretes Ig/Ig subunit. It is characterized by increased numbers of plasma cells in BM, monoclonal gammopathy, osteolysis, light chain proteinuria, hypercalcemia, cytopenias, and renal amyloidosis.
Multiple Myeloma
77
Disease characterized by painful, swollen lymph nodes with focal areas of necrosis.
Bubonic Plague
78
Meat spleen can be generally caused by
Phagocytosis
Proliferation of Cells
Storage of material
79
Disease of equines that is characterized by immune mediated hemolysis and decreased erythropoeisis leading to bone marrow hyperplasia
Equine Infectious Anemia
80
Primary neoplasias of the bone marrow are divided into
Lymphoproliferative Disorders
Myeloproliferative Disorders
81
Condition
Splenosis
\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_
Splenic rupture lead to seeding of the omentum and formation of numerous "accessory spleens"
82
Splenic nodules with a firm consistency could be
Splenic nodular hyperplasia
Fibrohistiocytic nodules
Primary neoplasms
Secondary neoplasms
Granulomas
Abscesses
83
Etiology
Bovine Enzootic Leukosis
84
Degenerative lesion of the spleen
Siderofibrosis
85
Likely etiology of granulomatious osteomyelitis
Fungal infection
86
Splenic rupture leading to seeding of the omentum and formation of numerous accessory spleens
Splenosis - Splenic Rupture
87
Differential diagosis for thymic atrophy
EHV 1
FeLV
Feline Panleukemia
BVD
Canine Distemper
88
Disease of chickens that is characterized by the proliferation of B lymphocytes.
Lymphoid Leukosis
89
Possible DDX
Multiple Myeloma
Osteomyelitis
90
Disease
Lymphosarcoma
91
Etiology
Corynebacterium pseudotuberculosis
92
Replacement of myeloid tissue by abnormal tissue
Myelophthisis
93
(Lympho/Myelo)-proliferative diseases are more common.
Lymphoproliferative Diseases
94
Disease characterized by greenish coored pus that becomes caseous with age.
Caseous Lymphadenitis
95
Etiology of Marek's Disease
Herpesvirus
96
Two common locations for hemangiosarcomas
Subcutis
Right Atrium
97
Disease
Caseous Lymphadenitis
98
Condition
Nodular Hyperplasia
99
Common disease that causes Myelophthisis
Scurvy - Vitamin C Deficiency
100
Differential Diagnosis for thymic hypoplasia
Severe Combined Immunodeficiency (SCID)
X- Linked Gene
101
Describe the appearance of porcine lymph nodes
Inverted cortex and medulla
102
Disease
Serous Atrophy of Fat
103
Rare neoplasm of the bone marrow that is usually benign and of the skin or mucous membrane origin.
Cutaneous Plasmocytoma
104
Non neoplastic canine immunoregulatory disorders
Cutaneous Histocytosis
Systemic Histocytosis
105
Condition
Histiocytic Sarcoma
106
Disease of the spleen caused by chronic antigenic stimulation leading to hyperplasia of the monocyte-macrophage or lymphoid/plasma cell population
Hyperplastic splenitis
107
Etiology
Mycobacterium bovis
108
Disease
Suppurative Osteomyelitis
109
Lesion
Myelofibrosis
\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_
Can be caused by Scurvy in guinea pigs
110
In the embryo, hematopoietic cells originate in the
Yolk Sac
111
Differential diagnosis for granulomatous lymphadenitis
Mycobacterium bovis
Histoplasma capsulatum
Post weaning Multisystemic Wasting Disease
112
Disease characterized by hyperplastic cell lines (one or multiple) and red marrow replacement by yellow marrow.
Bone Marrow Hyperplasia
113
Pathogenesis of Cytauxzoonosis
Schizogenous phase → Macrophages = Systemic Illness
Erythrocytic phase = Anemia
114
Etiology of Lymphoid leukosis in chickens
Avian Leukosis Virus
115
Bone marrow disease characterized by ineffective and dysplastic hematopoiesis. Diagnosed based on presence of decreased blasts in bone marrow ( \< 30%), cytopenia of \> 1 cell line and evidence of dyshematopoiesis.
Myelodysplastic Syndrome (MDS)
116
Release of immature cells from the bone marrow indicates
Stress or disease
117
The bursa of fabricius is populated by what type of lymphocytes
B lymphocytes
118
Main components of the hematopoietic system
Bone marrow
Blood cells
Lymph nodes and lymphatics
Spleen
Mucosa Associated Lymphoid Tissue (MALT)
Thymus
119
Clinical pathology associated with Splenic Hemangiosarcomas
Anemia
Thrombocytopenia
Increased hepatic enzymes
Schistocytes
120
Differential diagnosis for nodular hyperplasia
Lymphoma
Granulomatous infection
121
Histologic lesion associated with pigs infected with PMWS
"Botryoid" Intracytoplasmic Inclusions in Macrophages
122
Primary neoplasia of the lymphnode characterized by mottled pale tane and red appearance that is slightly buldging and nodular.
Lymphosarcoma
123
Disease and etiology
Herpes inclusion body disease
Columbid herpesvirus 1 (CoHV-1)
124
Etiology
Bacillus anthracis
125
Indolent cutaneous neoplasm of bone marrow. Probably of dendritic cell origin
Feline Progressive Histiocytosis
126
Splenomegaly caused by
Barbiturate euthanasia
