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Flashcards in Endocrinology Deck (168)
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1

sequence of male puberty

testicular growth, pubarche, penile growth, peak height velocity

2

testicular length that indicates start of puberty

>2.5 cm

3

onset of puberty for males is usually

10 to 11

4

sequence of female puberty

breast budding, pubarche, peak height velocity, menarche

5

puberty before what age is abnormal in females

8

6

delayed puberty ages

13 girls, 14 boys

7

most common cause of delayed puberty in boys

constitutional delay of puberty

8

common cause of delayed puberty in girls

functional gonadotropin deficiency (ex: anorexia) or primary ovarian failure (ex: turners)

9

axillary hair, pubic hair, acne, body odor without breast development or growth spurt

premature adrenarche

10

lab findings in premature adrenarche

elevated DHEA and DHEA-S, low testosterone

11

premature adrenarche in girls could indicate

PCOS

12

premature adrenarche in overweight due to

insulin resistance

13

development of secondary sexual characteristics with acceleration of linear growth or advanced bone age

true precocious puberty (before 9 in boy, 8 in girls)

14

consequence of precocious puberty

short adult height

15

treatment for precocious puberty

usually none but can use leuprolide (GnRH agonist)

16

micropenis and hypoglycemia

panhypopituitarism

17

blind ending vagina without a uterus

androgen insensitivity

18

mullerian inhibiting factor

stops uterus and ovaries from developing in males

19

most common cause of adrenal insufficiency in infants

congenital adrenal hyperplasia

20

excessive scrotal pigmentation in males

congenital adrenal hyperplasia

21

rugged labia and shock like picture

congenital adrenal hyperplasia

22

deficiency in CAH

21-hydroxylase

23

levels that are high in CAH

17-hydroxyprogesterone

24

newborn screening for CAH

17-hydroxyprogesterone

25

next step if 17-hydroxyprogesterone is elevated on newborn screen

repeat it, if still positive then measure electrolytes and urine Na, urine K+

26

CAH treatment

hydrocortisone (high doses = mineralocorticoid and glucocorticoid effects)

27

lab findings in adrenal crisis

hypoglycemia, hyponatremia and hyperkalemia

28

adrenal crisis treatment

20/Kg D5NS over one hour then IV hydrocortisone. replace glucocorticoid once crisis is treated

29

adrenal insufficiency may have what lab value elevated

ADH

30

hyperpigmentation in Addisons is due to

increased ACTH released from brain (trying to stimulate aldosterone)