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Flashcards in Heme/Onc Deck (180)
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1

physiologic drop in H/H occurs when in infants

2nd to 3rd month of life (8-10 wks) in full term, 1 to 2 months (7-8 wks) in preemies

2

etiology of physiologic anemia in newborns

low EPO production

3

normal MCV calculation

70 + 2(age in yrs)

4

normal MCV in children

70-90

5

microcytic anemia MCV

<70

6

hemoglobin F composition

2 alpha and 2 gamma chains

7

hemoglobin A composition

2 alpha and 2 beta chains

8

hemoglobin A2 composition

2 alpha and 2 delta chains

9

hemoglobin bart

on neonatal electrophoresis with alpha thalassemia (gamma chains)

10

one defective alpha allele

asymptomatic alpha thalassemia

11

2 defective alpha alleles

asymptomatic but with mild microcytic hypochromic anemia form of alpha thalassemia

12

3 defective alpha alleles

alpha thalassemia causing hemoglobin H disease leading to hemolysis and hepatomegaly - treated with splenectomy

13

hemoglobin H disease

alpha thalassemia with 3 defective alpha alleles, treatment is splenectomy

14

4 defective alpha alleles

alpha thalassemia that causes hydros fettles and results in stillbirth or death soon after birth

15

beta thalassemia minor aka

beta thalassemia trait

16

defect in one beta globulin gene allele

beta thalassemia minor - asymptomatic with incidental mild microcytic anemia

17

beta thalassemia minor on electrophoresis

elevated A2, normal iron

18

beta thalassemia intermedia

mutation in both beta globulin gene alleles but one mutation with a mild phenotype

19

beta thalassemia major

mutation in both beta globulin gene alleles with severe phenotype

20

xray with hair on end appearance of bone

in beta thalassemia major 2/2 extra medullary hematopoiesis

21

beta thalassemia major treatment

chronic transfusions

22

2 long term complications of chronic transfusions

cholelithiasis and hemosiderosis (iron deposits in liver, heart and pancreas)

23

sickle cell anemia on electrophoresis

hemoglobin F and hemoglobin S

24

beta thalassemia on electrophoresis

low/no A1, elevated Hgb A2 and Hgb F

25

treat iron deficiency anemia for how long

ferrous sulfate for 2 months after Hgb normalizes

26

RDW in iron deficiency and thalassemia

RDW high in iron deficiency anemia and lead toxicity, low/normal in thalassemia

27

gold standard test for lead toxicity

whole blood lead level

28

smear finding with lead toxicity

ringed sideroblast

29

MCV in microcytic anemias

>100

30

frequent causes of vitamin B12 deficiency

intrinsic factor deficiency (pernicious anemia), bacterial overgrowth, bowel resection, vegetarian diet, HLA-B27/Crohn's