Enzymes 1

Question 1

Transition State

Answer 1

The state between substrate and product

Question 2

Prosthetic Group

Answer 2

Tightly bound cofactors (that are not proteins)

Question 3

4 Ds (symptoms of disease)

Answer 3

Dermatitis
Diarrhoea
Dementia
–> Death

Question 4

Steric Hindrance

Answer 4

Side chains in amino acids banging into one another; it is not thermo-dynamically favourable

Question 5

Isozymes

Answer 5

Enzymes that differ in amino acid sequence but catalyse the same reaction

Question 6

Benefits of Multi enzyme complexes

Answer 6

Reduced transit time via diffusion and decreased interference as products are acted upon by the correct enzyme

Question 7

What are cofactors generally synthesised from

Answer 7

Vitamins

Question 8

Lactate Dehydrogenase

Answer 8

Catalyses the transfer of electrons from lactate to NAD+

Question 9

Consequence of lack of Niacin from diet

Answer 9

NAD+ molecules are needed to convert pyruvate to lactate so a lack of niacin means a lack of lactate (bad)