Epilepsy Drugs Flashcards Preview

Drugs > Epilepsy Drugs > Flashcards

Flashcards in Epilepsy Drugs Deck (11):
1

Epilepsy drugs that block/inactivate sodium channels

Phenytoin
Carbamazepine
Valproic Acid
Topiramate
Lamotrigine

2

Blocks thalamic T-type Ca2+ channels.
DOC for absence seizures.
SE: constipation, urticaria, SJS.

Ethosuximide

3

Potentiates GABAa by inc FREQUENCY of chloride channel openings; DOC acute status epileptics, second line for eclampsia seizures

Benzos

4

DOC eclampsia seizures

MgSO4 (benzos are second line)

5

Inactivates sodium channels.
Zero order kinetics.
SE: gingival hyperplasia, SLE, megaloblastic anemia, fetal hydantoin syndrome,
Induces P450!

Phenytoin

6

Inactivates sodium channels.
DOC for partial seizures.
SE: Blood dyscrasias (agranulocytosis + aplastic anemia), SIADH, SJS

Carbamazepine

7

Inactivates sodium channels and increases GABA by inhibiting GABA transaminase.
DOC: myoclonic seizures
SE: neural tube defects in fetus, hepatotoxic

Valproic acid

8

Inactivates high-voltage-activated Ca+ channels. Designed as a GABA analog.
Also used for peripheral neuropathy, postherpetic neuralgia, migraine prophylaxis, bipolar disorder
SE: ataxia, sedation

Gabapentin

9

Potentiates GABA(a) by inc DURATION of chloride channel openings.
CI in porphyria.
DOC infant epilepsy
SE: induces 450, cardioresp depression

Phenobarbital

10

Blocks sodium channels and inc GABA action.
Also used for migraine prophylaxis.
SE: kidney stones, weight loss

Topiramate

11

Blocks voltage-gated sodium channels. Used for epilepsy and bipolar maintenance.
SE: SJS (titrate slowly)

Lamotrigine