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Flashcards in FA GI Pharm Deck (39):
1

Reversible block of histamine H2-receptors --> decreased H+ secretion by parietal cells

H2 blockers

2

Irreversibly inhibit H+/K+ ATPase in stomach parietal cells

Proton pump inhibitors

3

Bind to ulcer base, providing physical protection and allowing HCO3- secretion to reestablish pH gradient in the mucous layer

Bismuth, sucralfate

4

A PGE1 analog. Increased production and secretion of gastric mucous barrier, decreased acid production

Misoprostol

5

Long-acting somatostatin analog

Octreotide

6

Provide osmotic load to draw water out

Osmotic laxatives

7

treats hepatic encephalopathy since gut flora degrade it into metabolites (lactic acid and acetic acid) that promote nitrogen excretion as NH4+

Lactulose

8

Monoclonal antibody to TNF-alpha

Infliximab

9

A combination of sulfapyridine (antibacterial) and 5-aminosalicyclic acid (anti-inflammatory). Activated by colonic bacteria.

Sulfasalazine

10

5-HT3 antagonist; decreased vagal stimulation. Powerful central-acting antiemetic

Ondansetron

11

D2 receptor antagonist. Increased resting tone, contractility, LES tone, motility. Does not influence colonic transport time

Metoclopramide

12

CU: peptic ulcer, gastritis, mild esophageal reflux

H2 blockers

13

Ex: cimetidine, ranitidine, famotidine, nizatidine

H2 blockers

14

Ex: omeprazole, lanzoprazole, esmoeprazole, pantoprazole, dexlansoprazole

PPIs

15

CU: peptic ulcer, gastritis, esophageal reflux, ZES

PPIs

16

Tox: increased risk of C diff infxn, pneumonia, hip fractures, decreased serum Mg with long term use

PPIs

17

CU: increased ulcer healing, traveler's diarrhea

Bismuth, sucralfate

18

Potent inhibitor of cytochrome P450; anti androgen effects; can cross BBB and placenta, decreases renal excretion of creatinine

Cimetidine

19

CU: prevention of NSAID-induced peptic ulcers (NSAIDs block PGE1 production); maintenance of a PDA; also used to induce labor ("ripens cervix").

Misoprostol

20

Tox: Diarrhea, abortifacient

Misoprostol

21

CU: acute variceal bleeds, acromegaly, VIPoma, carcinoid

Octreotide

22

Tox: nausea, cramps, steatorrhea

Octreotide

23

Tox (group): can affect absorption, bioavailability, or urinary excretion of other drugs by altering gastric and urinary pH or by delaying gastric emptying; hypokalemia

Antacids

24

Tox: Constipation and hypophosphatemia; proximal muscle weakness, osteodystrophy, seizures

Aluminum hydroxide

25

Tox: Hypercalcemia, rebound acid increase, can chelate and decrease effectiveness of other drugs (tetracycline)

Calcium carbonate

26

Tox: diarrhea, hyporeflexia, hypotension, cardiac arrest

Magnesium hydroxide

27

Cu: constipation

osmotic laxatives

28

Ex: Mg hydroxide, Mg citrate, polyethylene glycol, lactulose

osmotic laxatives

29

CU: Crohn's, UC, RA, ankylosing spondylitis, psoriasis

Infliximab

30

CU: UC, Crohn's

Sulfasalazine

31

CU: control vomiting postoperatively and in pts undergoing cancer chemotherapy

Ondansetron

32

CU: diabetic and post-surgery gastroparesis, antiemetic

Metoclopramide

33

Tox: diarrhea, dehydration; may be abused by bulimics

osmotic laxatives

34

Tox: infection, reactivation of latent TB, fever, hypotension

Infliximab

35

Tox: malaise, nausea, sulfonamide toxicity, reversible oligospermia

Sulfasalazine

36

Tox: headache, constipation

Ondansetron

37

Tox: increased parkinsonian effects. restlessness, drowsiness, fatigue, depression, nausea, diarrhea.

Metoclopramide

38

Metoclopramide is notable for drug interactions with what types of meds?

Digoxin, diabetic agents

39

Metoclopramide is contraindicated in what conditions?

Small bowel obstruction or Parkinson dz (D1-receptor blockade)