FA Immuno Pharm Flashcards Preview

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Flashcards in FA Immuno Pharm Deck (59):
1

CU epoetin alfa (erythropoietin)

Anemias, esp in renal failure

2

CU thrombopoietin

Thrombocytopenia

3

CU oprelvekin (IL-11)

Thrombocytopenia

4

CU filgrastim (G-CSF)

Recovery of bone marrow

5

CU sargamostim (GM-CSF)

Recovery of bone marrow

6

CU Aldesleukin (IL-2)

Renal cell carcinoma, metastatic melanoma

7

CU IFN-alpha

Chronic hepatitis B and C,
Kaposi sarcoma,
Hairy cell leukemia,
condyloma acuminatum,
renal cell carcinoma,
Malignant melanoma

8

CU IFN-beta

MS

9

CU IFN-gamma

CGD

10

Alemtuzumab =

anti-CD52

11

Bevacizumab =

anti-VEGF

12

Cetuximab =

anti-EGFR

13

Rituximab =

anti-CD20

14

Trastuzumab =

anti-HER2/neu

15

CU alemtuzumab

CLL

16

CU bevcizumab

colorectal cancer, RCC

17

CU cetuximab

stage IV colorectal cancer, head and neck cancer

18

CU rituximab

B-cell non-Hodgkin lymphoma,
RA (with MTX),
ITP

19

CU trastuzumab

Breast cancer, gastric cancer

20

Infliximab =

anti-TNF-alpha

21

Adalimumab =

anti-TNF-alpha

22

CU infliximab

IBD, RA, ankylosing spondylitis, psoriasis

23

CU adalimumab

IBD, RA, ankylosing spondylitis, psoriasis

24

Natalizumab =

anti-alpha4-integrin

25

alpha4-integrin is important for:

leukocyte adhesion

26

CU natalizumab

MS, Crohn disease

27

SE natalizumab

risk of PML in patients with JC virus

28

Abciximab =

anti-glycoprotein IIb/IIIa

29

CU abciximab

anti-platelet agent for prevention of ischemic complications in patients undergoing percutaneous coronary intervention

30

Denosumab =

anti-RANKL

31

CU denosumab

osteoporosis: inhibits osteoclast maturation (mimics osteoprotegrin)

32

CU digoxin immune Fab

Antidote for digoxin toxicity

33

Omalizumab =

anti-IgE

34

CU omalizumab

allergic astma: prevents IgE binding to FCepsilonRI (add on therapy)

35

Palivizumab =

anti-RSV F protein;

36

CU palivizumab

RSV prophylaxis for his risk infants

37

Calcineurin inhibitor; binds cyclophilin. Blocks T cell activation by preventing IL-2 transcription

Cyclosporine

38

CU cyclosporine

transplant rejection prophylaxis, psoriasis, RA

39

Tox cyclosporine

- Nephrotoxicity,
- HTN, hyperlipidemia, hyperglycemia,
- Tremor
- Hirsuitism, gingival hyperplasia

40

Calcineurin inhibitor; binds FK506 binding protein (FKBP); blocks T cell activation by preventing IL-2 transcription

Tacrolimus
(note that all -limus drugs bind FKBP!)

41

CU Tacrolimus

Transplant rejection prophylaxis

42

Tox tacrolimus

- Diabetes & neurotoxicity (more than cyclosporine)
- Nephrotoxicity,
- HTN, hyperlipidemia, hyperglycemia,
- Tremor

43

mTOR inhibitor; binds FKBP; blocks T cell activation and B cell differentiation by preventing IL-2 signal transduction

Sirolimus (rapamycin)

44

CU sirolimus (rapamycin)

kidney transplant rejection prophylaxis

45

Tox sirolimus (rapamycin)

anemia, thrombocytopenia, leukopenia, hyperlipidemia, but NOT nephrotoxic

46

Basiliximab =

anti-IL-2R

47

CU Basiliximab

kidney transplant prophylaxis

48

Tox Basiliximab

Edema, HTN, tremor

49

Antimetabolite precursor of 6-MP; inhibits lymphocyte proliferation by blocking nucleotide synthesis

Azathioprine

50

CU azathioprine

transplant rejection prophylaxis;
RA; Crohns; glomerulonephritis;
other AI

51

Tox azathioprine

- leukopenia, anemia, thrombocytopenia
- NB: 6-MP is degraded by xanthine oxidase, so toxicity is increased by allopurinol

52

Inhibit NF-kappaB; suppress B and T cell fxn by decreasing transcription of many cytokines

glucocorticoids

53

CU glucocorticoids

transplant rejection prophylaxis, AI diseases, inflammation

54

Tox glucocorticoids

hyperglycemia, osteoporosis, central obesity, muscle breakdown, psychosis, acne, HTN, cataracts, peptic ulcers

55

MOA cyclosporine

Calcineurin inhibitor; binds cyclophilin. Blocks T cell activation by preventing IL-2 transcription

56

MOA tacrolimus

Calcineurin inhibitor; binds FK506 binding protein (FKBP); blocks T cell activation by preventing IL-2 transcription

57

MOA sirolimus (rapamycin)

mTOR inhibitor; binds FKBP; blocks T cell activation and B cell differentiation by preventing IL-2 signal transduction

58

MOA azathioprine

Antimetabolite precursor of 6-MP; inhibits lymphocyte proliferation by blocking nucleotide synthesis

59

MOA glucocorticoids

Inhibit NF-kappaB; suppress B and T cell fxn by decreasing transcription of many cytokines