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Flashcards in FA MSK Pharm Deck (10):
1

Reversibly inhibit COX 1&2. Block PG synthesis. Indomethacin closes PDA
SE: interstitial nephritis, gastric ulcer, renal ischemia

NSAIDs.

2

Reversibly inhibit COX2 (spares COX-1, wh/ helps maintain the gastric mucosa; spares platelet function as TXA2 production is dependent on COX1);
SE: increased risk of thrombosis (through PGI2?), sulfa allergy

COX-2 inhibitors (celecoxib)

3

Reversibly inhibits COX, mostly in CNS; inactivated peripherally.
SE: centrilobular hepatic necrosis, NAPQI depletes glutathione (NAC regenerates)

Acetaminophen

4

Pyrophosphate analogs; bind hydroxyapatite in bone, inhibiting osteoclast activity
SE: corrosive esophagitis, osteonecrosis of jaw

Bisphosphonates

5

Inhibits xanthine oxidase. Used to prevent chronic gout and tumor lysis, increases conc of azathioprine and 6-MP. Do not give salicylates, which depress uric acid clearance.

Allopurinol, febuxostat

6

Inhibits reabsorption of uric acid in PCT (also inhibits secretion of PCN). Don't use in renal failure or tumor lysis.

Probenecid

7

Binds and stabilizes tubulin to inhibit microtubule polymerization, impairing leukocyte chemotaxis and degranulation.
SE: GI

Colchicine

8

Fusion protein (receptor for TNF-alpha and IG1 Fx), produced by recombinant DNA.
CU: RA, psoriasis, ankylosing spondylitis

Etanercept

9

Anti-TNF-alpha monoclonal antibody.
CU: IBD, RA, ank spond, psoriasis
SE: reactivates TB

Infliximab, adalimumab

10

Irreversibly inhibits COX-1 and COX-2 by covalent acetylation, which decreases TXA2 and PGs. Increased BT for >7 days.
SE: gastric ulcers, tinnitis, Reyes (microvesicular hepatic steatosis - mitrochondrial dysfxn) in kids, OD: resp alkalosis then met acidosis (combo)

ASA