FA G-protein linked second messengers Flashcards Preview

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Flashcards in FA G-protein linked second messengers Deck (23):
1

Vasoconstriction, pupil dilation, intestinal and bladder sphincter contraction

Alpha1 agonist (e.g., phenylephrine)

2

Vasodilation, pupil constriction, intestinal and bladder sphincter relaxation

Alpha1 antagonist (e.g., tamsulosin)

3

Decreased sympathetic outflow, insulin release, lipolysis, and aqueous humor production, increased platelet aggregation

Alpha2 agonist (e.g., clonidine, alpha-methyldopa, bromonidine)

4

Increased sympathetic outflow, insulin release, and lipolysis; decreased platelet aggregation

Alpha2 antagonist (e.g., mirtazapine)

5

Increased HR, contractility, renin, lipolysis

Beta1 agonist (e.g., dobutamine)

6

Decreased HR, contractility, renin, lipolysis

Beta1 antagonist (e.g., metoprolol)

7

- Vasodilation, bronchodilation
- increased HR, contractility, lipolysis, insulin release
- inc aqueous humor prod
- ciliary muscle relaxation
- decreased uterine tone (tocolysis)

Beta2 agonist (e.g., albuterol, terbutaline)

8

- vaso & bronchoconstriction
- decreased HR, contractility, lipolysis, insulin release
- dec aqueous humor prod
- ciliary muscle contraction (accommodation)
- increased uterine tone

Beta2 antagonist

9

CNS, enteric nervous system

M1

10

decreased HR and contractility of atria

M2 agonist

11

increased HR and contractility of atria

M2 antagonist (e.g., atropine)

12

increased exocrine gland secretion, gut peristalsis, bladder contraction, bronchoconstriction, pupil constriction, ciliary muscle contraction (accommodation)

M3 agonist

13

Cholinesterase inhibitor poisoning (i.e., nonselective muscarinic agonist)

DUMBBELS
Diarrhea
Urination
Miosis
Bronchospasm
Bradycardia
Exc of skeletal musc. & CNS
Lacrimation
Sweating
Salivation

14

Relaxes renal vascular smooth muscle

D1

15

Modulates transmitter release, especially in the brain

D2

16

Increased nasal and bronchial mucus production, increased vascular permeability, contraction of bronchioles, pruritus, pain

H1

17

Increased gastric acid secretion

H2

18

Increased vascular smooth muscle contraction

V1

19

Increased H2O permeability and reabsorption in the CTs of the kidney

V2

20

Atropine toxicity (ie. nonselective muscarinic antagonist)

Hot as a hare
Dry as a bone
Red as a beet
Blind as a bat
Mad as a hatter

21

Which receptors use Gq --> PLC --> IP3 --> increased calcium? (and DAG --> PKC)

H1, alpha1, V1, M1, M3

22

Which receptors use Gs --> increased cAMP?

Beta1, beta2, D1, H2, V2

23

Which receptors use Gi --> decreased cAMP?

M2, alpha2, D2