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Flashcards in FA Repro Pharm Deck (16):
1

GnRH analog with agonist properties when used in pulsatile fashion; antagonistic properties when used in continuous fashion

Leuprolide

2

Antagonist at estrogen receptors in hypothalamus. Prevents normal feedback inhibition and increased release of LH and FSH from pituitary, which stimulates ovulation.

Clomiphene

3

Antagonist on breast tissue; agonist at uterus, bone;

Tamoxifen

4

Agonist on bone; antagonist at uterus

Raloxifene

5

Aromatose inhibitors used in postmenopausal women with breast cancer

Anastrozole/exemestane

6

Bind progesterone receptors, decrease growth and increase vascularization of endometrium

Progestins

7

Competitive inhibitor of progestins at progesterone receptors

Mifepristone (RU-486)

8

Beta2-agonist that realizes the uterus; used to decrease contraction frequency in women during labor

Terbutaline

9

Synthetic androgen that acts as partial agonist at androgen receptors

Danazol

10

Agonist at androgen receptors

Testosterone, methyltestosterone

11

5alpha-reducatase inhibitor (decreases conversion of testosterone to DHT).

Finasteride

12

A non-steroidal competitive inhibitor of androgens at the testosterone receptor. Used in prostate carcinoma.

Flutamide

13

Inhibits steroid synthesis (inhibits 17,20-desmolase)

Ketoconazole

14

Inhibits steroid binding, 17-alpha-hydroxylase, and 17,20-desmolase

Spironolactone

15

Alpha1-antagonist used to treat BPH by inhibiting smooth muscle contraction. Selective for alpha1A,D receptors (found on prostate) vs. vascular alpha1B receptors.

Tamsulosin

16

Inhibits phosphodiesterase 5, causing increased cGMP, smooth muscle relaxation in the corpus cavernous, increased blood flow, and penile erection

Sildenafil, vardenafil