Epilepsy Drugs Flashcards Preview

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Flashcards in Epilepsy Drugs Deck (26)
1

First line drug for simple partial seizures

Carbamazepine

2

First line drug for complex partial seizures

Carbamazepine

3

First line drugs for tonic clonic seizures

Phenytoin, carbamazepine, valproic acid

4

First line drug for absence seizures

Ethosuximide

5

First line drug for acute status epilepticus

Benzodiazepines (diazepam or lorazepam)

6

First line prophylaxis for status epilepticus

Phenyotin

7

First line drug for trigeminal neuralgia

Carbamazepine

8

Epileptic drug used as migraine prophylaxis

Topiramate

9

MOA of phenytoin

Increases Na channel inactivation

10

MOA of carbamazepine

Increases Na channel inactivation

11

MOA of lamotrigine

Blocks voltage gated Na channels

12

MOA of gabapentin

Designed as GABA analog, but primarily inhibits high-voltage activated Ca channels

13

MOA of topiramate

Blocks Na channels, increases GABA action

14

MOA of phenobarbital

Increases GABAa action

15

MOA of valproic acid

Increases Na channel inactivation, increases GABA concentration

16

MOA of ethosuximide

Blocks thalamic T-type Ca channels

17

MOA of benzodiazepines

Increases GABAa action

18

MOA of tigabine

Inhibits GABA reuptake

19

MOA of vigabatrin

Irreversibly inhibits GABA transaminase which increases GABA

20

Alternative use for gabapentin other than seizures

Peripheral neuropathy and postherpetic neuralgia

21

Anti-epileptic that an also be used for seizures of eclampsia

Benzodiazepines

22

Anti-epileptic drugs that can cause Stevens-Johnson syndrome

Carbamazepine, ethosuximide, phenytoin, lamotrigine

23

Main side effects of carbamazepine

Diplopia, ataxia, blood dyscrasias (agranulocytosis, aplastic anemia), liver toxicity

24

Main side effects of phenytoin

Gingival hyperplasia, hirsutism, teratogenesis, SLE-like syndrome

25

Main side effects of gabapentin

Sedation, ataxia

26

Main side effects of topiramate

Sedation, mental dulling, kidney stones, weight loss