Common Teratogens and Associated Effects Flashcards Preview

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Flashcards in Common Teratogens and Associated Effects Deck (20)
1

Teratogen: alcohol

Most common cause of mental retardation; also leads to facial abnormalities and microcephaly

2

Teratogen: cocaine

Intrauterine growth retardation and placental abruption

3

Teratogen: thalidomide

Limb defects ("flipper limbs")

4

Teratogen: cigarette smoke

Intrauterine growth retardation, preterm labor, placental problems, ADHD

5

Teratogen: isotretinoin

Spontaneous abortion, hearing and visual impairment

6

Teratogen: tetracycline

Discolored teeth

7

Teratogen: warfarin

Bone deformities, fetal bleeding, abortion, ophthalmologic abnormalities

8

Teratogen: phenytoin

Fetal hydantoin syndrome: microcephaly, dysmorphic craniofacial features, hypoplastic nails and distal phalanges, cardiac defects, intrauterine growth retardation, mental retardation

9

Teratogen: ACE inhibitors

Renal damage

10

Teratogen: alklyating agents

Absence of digits, multiple anomalies

11

Teratogen: aminoglycosides

CN VIII toxicity

12

Teratogen: carbamazepine

Neural tube defects, craniofacial defects, fingernail hypoplasia, developmental delay, intrauterine growth retardation

13

Teratogen: diethylstilbestrol (DES)

Vaginal clear cell adenocarcinoma, congenital Mullerian anomalies

14

Teratogen: folate antagonists

Neural tube defects

15

Teratogen: lithium

Ebstein's anomaly (atrialized right ventricle)

16

Teratogen: valproate

Inhibition of maternal folate absorption - neural tube defects

17

Teratogen: iodine (lack or excess)

Congenital goiter or hypothyroidism (cretinism)

18

Teratogen: maternal diabetes

Caudal regress syndrome (anal atresia to sirenomelia), congenital heart defects, neural tube defects

19

Teratogen: vitamin A (excess)

Extrememly high risk for spontaneous abortions and birth defects (cleft palate, cardiac abnormalities)

20

Teratogen: X-rays

Microcephaly, mental retardation