Bacterial Toxin Mechanism of Action Flashcards Preview

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Flashcards in Bacterial Toxin Mechanism of Action Deck (19)
1

MOA of Bacillus anthracis (edema factor)

PA+EF = increases cAMP

2

MOA of Bacillus anthracis (lethal factor)

PA+LF = zinc dependent protease that cleaves MAP kinase leading to cell death

3

MOA of Bordetella pertusis toxin

Overactivates AC increasing cAMP by disabling Gi, impairing phagocytosis to permit survival

4

MOA of Clostridium botulinum toxin

Cleaves SNARE protein required for NT release, prevents release of ACh

5

MOA of Clostridium difficile (toxin A, toxin B)

A= enterotoxin, binds to brush border of the gut

B= cytotoxin, destroys the cytoskeletal membrane

6

MOA of Clostridium perfringens (alpha toxin)

Phospholipase that degrades tissue and cell membranes

7

MOA of Clostridium tetani toxin

Cleaves SNARE protein required for NT release, prevents release of GABA and glycine

8

MOA of Corynebacterium diptheriae

Inactivates elongation factor 2 (EF-2)

9

MOA of EHEC

Inactivates 60S ribosome by removing adenine from rRNA

10

MOA of ETEC (heat-labile toxin)

Overactivates AC which increases cAMP

11

MOA of ETEC (heat-stable toxin)

Overactivates GC which increases cGMP

12

MOA of lipopolysaccharide (endotoxin)

Produces inflammatory response

13

MOA of Pseudomonas aeruginosa

Inactivates elongation factor 2 (EF-2)

14

MOA of Shigella species

Inactivates 60S ribosome by removing adenine from rRNA

15

MOA of Staphylococcus aureus (enterotoxin)

Stimulates cytokine release and inflammation

16

MOA of Staphylococcus aureus (exfoliative toxin)

Breaks down desmosomes within epidermis

17

MOA of Staphylococcus aureus (TSST-1)

Brings MCH-II and TCR in proximity causing release of IFN-gamma and IL-2

18

MOA of Streptoccocus pyogenes (streptolysin O)

Protein that degrades cell membrane

19

MOA of Vibrio cholerae toxin

Permanently activates Gs, increasing cAMP