G-protein-linked 2nd Messengers Flashcards Preview

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Flashcards in G-protein-linked 2nd Messengers Deck (13)
1

G-protein class and major functions of alpha-1

- Gq
- increases smooth muscle contraction
- increases pupillary dilator muscle contraction (mydriasis)
- increases intestinal and bladder sphincter muscle contraction

2

G-protein class and major functions of alpha-2

- Gi
- decreases sympathetic outflow
- decreases insulin release
- decreases lipolysis
- increases platelet aggregation

3

G-protein class and major functions of beta-1

- Gs
- increases heart rate
- increases contractility
- increases renin release
- increases lipolysis

4

G-protein class and major functions of beta-2

- Gs
- vasodilation
- bronchodilation
- increases heart rate
- increases contractility
- increases lipolysis
- increases insulin release
- decreases uterine tone (tocolysis)
- ciliary muscle relaxation
- increases aqueous humor production

5

G-protein class and major functions of M1

- Gq
- CNS
- enteric nervous system

6

G-protein class and major functions of M2

- Gi
- decreases heart rate and contractility of atria

7

G-protein class and major functions of M3

- Gq
- increases exocrine gland secretions (e.g., lacrimal, gastric acid)
- increases gut peristalsis
- increases bladder contraction
- bronchoconstriction
- increases pupillary sphincter muscle contraction (miosis)
- ciliar muscle contraction (accommodation)

8

G-protein class and major functions of D1

- Gs
- relaxes renal vascular smooth muscle

9

G-protein class and major functions of D2

- Gi
- modulates transmitter release, especially in brain

10

G-protein class and major functions of H1

- Gq
- increases nasal and bronchial mucus production
- contraction of bronchioles
- pruritis and pain

11

G-protein class and major functions of H2

- Gs
- increases gastric acid secretion

12

G-protein class and major functions of V1

- Gq
- increases vascular smooth muscle contraction

13

G-protein class and major functions of V2

- Gs
- increases water permeability and reabsorption in the collecting tubules of the kidney (V2 is found in the 2 kidneys)