Tumor Suppressor Genes Flashcards Preview

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Flashcards in Tumor Suppressor Genes Deck (17)
1

Associated tumor(s) with Rb

Retinoblastoma, osteosarcoma

2

Gene product of Rb

Inhibits EF-2, blocks G1 to S phase

3

Associated tumor(s) with p53

Most human cancers, Li-Fraumeni syndrome

4

Gene product of p53

Transcription factor for p21, blocks G1 to S phase

5

Associated tumor(s) with BRCA1

Breast and ovarian cancer

6

Gene product of BRCA1

DNA repair protein

7

Associated tumor(s) with BRCA2

Breast and ovarian cancer

8

Gene product of BRCA2

DNA repair protein

9

Associated tumor(s) with p16

Melanoma

10

Associated tumor(s) with APC

Colorectal cancer (associated with FAP)

11

Associated tumor(s) with WT1

Wilm's tumor (nephroblastoma)

12

Associated tumor(s) with NF1

Neurofibromatosis type 1

13

Gene product of NF1

RAS GTPase activating protein (RAS-GAP)

14

Associated tumor(s) with NF2

Neurofibromatosis type 2

15

Gene product of NF2

Merlin (schwannomin) protein

16

Associated tumor(s) with DPC4

Pancreatic cancer

17

Associated tumor(s) with DCC

Colon cancer