Cardiology Biochem Flashcards Preview

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Flashcards in Cardiology Biochem Deck (18)
1

Function of apoAI

Activates LCAT; structural HDL component

2

Function of apoB48

Assembly/secretion of chlyomicrons from small intestine

3

Function of apoB100

VLDL assembly/secretion (liver)

VLDL, IDL, LDL structural protein

LDL receptor ligand for extrahepatic cells

4

Function of apoCII

Cofactor activator of LPL

5

Function of apoE

VLDL and chlyomicron remnant uptake by the liver

6

Function of apo (a)

Unknown; linked by disulfide bond to apoB100

7

Cause of familial hyperchylomicronemia (type I)

LDP or apo-CII deficiency

8

Lipoprotein fractions seen in familial hyperchylomicronemia (type I)

Increased chylomicrons
Increased TGs

9

Cause of familial hypercholesterolemia (type IIa)

Defect in LDL receptor

10

Lipoprotein fractions seen in familial hypercholesterolemia (type IIa)

Increased LDL

11

Cause of familial mixed hyperlipidemia (type IIb)

Defect in internalization of LDL receptor

12

Lipoprotein fractions seen in familial mixed hyperlipidemia (type IIb)

Increased LDL, VLDL, and TGs

13

Cause of familial dysbetalipoproteinemia (type III)

Defect in apo-E

14

Lipoprotein fractions seen in familial dysbetalipoproteinemia (type III)

Increased IDL (beta VLDL)
Increased chlyomicron remnants

15

Cause of familial hypertriglyceridemia (type IV)

Multiple factors

16

Lipoprotein fractions seen in familial hypertriglyceridemia (type IV)

Increased VLDL and TG

17

Cause of familial mixed hypertriglyceridemia (type V)

LPL deficiency plus increased VLDL production

18

Lipoprotein fractions seen in familial mixed hypertriglyceridemia (type V)

Increased VLDL, chlyomicrons, and TGs