Exam - Copper Flashcards
what does copper function as a component of
many important enzymes
enzymes that copper functions as a component of
ceruloplasmin
cytochrome c oxidase
superoxide dismutase
dopamine monoxygenase
tyrosinase
what is ceruloplasmin necessary for
iron metabolism
what is cytochrome c oxidase a key enzyme in
ETC
what is superoxide dismutase necessary for
oxidant defence system
what is dopamine monoxygenase key for
norepinephrine production
what is tyrosinase involved in
melanin formation
how does Cu2+ get transported
bound to amino acids
what releases Cu2+ from amino acids
HCl and pepsin
what must occur for copper to be absorbed
Cu2+ must be reduced to Cu1+
what happens to absorbed copper
is is transported to the liver bound to protein, where it gets incorporated into ceruloplasmin
what diseases is due to copper deficiency
Menke’s disease
general symptoms of menke’s disease
anaemia
hypopigmentation of skin, bone abnormalities, thrombosis
what is menke’s disease also called
kinky hair syndrome
