Exam - Iodine Flashcards

(40 cards)

1
Q

supplement label of iodine

A

thyroid gland support

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2
Q

is iodine prevalent in most foods

A

no, iodine content is low

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3
Q

what is iodine

A

inorganic mineral that is highly water soluble

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4
Q

where is iodine found in higher concentrations

A

in coastal populations opposed to mountainous regions

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5
Q

what kind of food has high iodine concentration

A

seafood - especially sea greens

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6
Q

where does most iodine consumed come from in North America

A

salt fortified with potassium iodine

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7
Q

how many mg of iodine does iodized salt contain per g of salt

A

0.03

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8
Q

as of 2007, what percentage of the world population live in areas of iodine deficiency

A

29%

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9
Q

how can dietary iodine be found

A

bound to amino acids or free

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10
Q

what occurs to iodine in our GI tract

A

iodine is rapidly converted to iodide (ionic form) and absorbed

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11
Q

where does iodine get absorbed

A

mostly in stomach, a bit in small intestine

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12
Q

what does free iodide do in blood

A

circulates and can enter all tissues

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13
Q

where does most of free iodide accumulate

A

thyroid gland

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14
Q

what percentage of the iodine in our body is located in the thyroid gland

A

70-80%

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15
Q

what is the uptake of iodide mediated by

A

active transport system: Na+/I- symporter (NIS)

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16
Q

do all tissues depend on iodine

A

no, all tissues depend on thyroid hormones T3 and T4 rather than iodine itself

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17
Q

what happens to T3 and T4 after they are made

A

they are released into blood and transported by carrier proteins

18
Q

is there more T4 or T3 in blood

A

50x more T4 than T3 in blood - but T3 is 100x more potent

19
Q

what does T3 interact with

A

thyroid hormone receptor

20
Q

what is T3 and T4 production regulated by

A

thyroid stimulating hormone

21
Q

what occurs when T3 levels are low

A

the hypothalamus signals to the pituitary to release TSH

22
Q

what is thyroglobulin (THG)

A

tyrosine-rich protein

23
Q

what do thyroid hormones influence

A

how body stores and uses energy

24
Q

things that thyroid hormones control

A
  • breathing
  • heart function
  • nervous system function
  • body temp
  • cholesterol level
  • energy balance
  • brain development
  • skin moisture
  • menstruation
25
what does it mean that T3 and T4 are lipophilic
they can easily cross plasma membranes
26
what does T3 do in tissues
binds to THR which then binds to response elements in promoter regions of DNA to activate gene expression
27
examples of genes activated by T3
ATPases Growth hormone
28
what does the pituitary gland release when T3 levels are low
TSH
29
what is occurring when iodine is deficient
the thyroid is still being stimulated by TSH to make hormones but it can't
30
what is the result of the thyroid being unable to make hormones
hyperplasia hypertrophy
31
hyperplasia
increase in cell number
32
hypertrophy
increase in cell size
33
result of iodine deficiency
goiter in adults cretinism
34
what is a goiter
thyroid enlargement
35
what is cretinism
when iodine levels are low in mother, fetus does not develop properly
36
what does goiter lead to
thyroid cancer if left untreated
37
what can mild goiters be treated with
iodine supplements
38
what does cretinism lead to
growth and developmental abnormalities - irreversible
39
how many people are affected by iodine deficiency disease
over 740 million (13% of world population)
40
how many people have some degree of intellectual disability caused by IDD
50 million