Exam - Vitamin C Flashcards

1
Q

supplement label for Vitamin C

A

antioxidant support

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2
Q

what is another name for Vit C

A

ascorbic acid (ascorbate at physiological pH)

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3
Q

which vitamin C isomer is biologically active in humans

A

L

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4
Q

which animals cannot synthesize vitamin C from glucose (making it essential)

A

humans
primates
fruit bats
guinea pigs
some birds

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5
Q

why can some animal not synthesize vitamin C from glucose

A

lack enzyme gulonolactone oxidase

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6
Q

what are the primary sources of vitamin c

A

fruits and veggies

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7
Q

does vitamin c require digestion prior to absorption

A

no

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8
Q

how is vitamin c taken up

A

via sodium-dependent vitamin C 1 and 2 transported in small intestine

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9
Q

what kind of mechanism is responsible for vitamin c uptake

A

feedback mechanism

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10
Q

what percentage of dietary vitamin C gets absorbed

A

70-90%

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11
Q

where are vitamin C concentrations high

A

in white blood cells and many tissues

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12
Q

examples of biological processes that vitamin c is involved in

A

collagen synthesis
tyrosine synthesis
neurotransmitter synthesis

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13
Q

in biological processes, how does vitamin c act primarily

A

as a reducing agent (2 electron donor)

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14
Q

how does vitamin C help in hydroxylation reaction in collagen

A

donates electron to aromatic proline to make Pro-OH so that collagen molecules can stick together

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15
Q

what percentage of the amino acids in pro collagen are prolines

A

30%, 1/3 are hydroxylated

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16
Q

what is the goal for vitamin C RDA

A

maximize tissue concentration and minimize urinary excretion (men more than women)

17
Q

signs of vitamin C deficiency

A

scurvy
increased risk of hemorrhages
increased hair loss and loose teeth
swollen joints and poor would healing

18
Q

why are there the issues with vitamin C deficiency

A

problems producing hydroxylproline (i.e collagen and hair loss)