Flashcards in GI - Cancers Deck (10)
Replacement of nonkeratinized stratified squamous epithelium with intestinal epithelium (nonciliated columnar with goblet cells) in the distal esophagus. Due to chronic acid reflux (GERD). Associated with esophagitis, esophageal ulcers, and increased risk of esophageal adenocarcinoma.
Squamous cell carcinoma of the esophagus
Occurs in the upper 2/3 of the esophagus.
I think this is associated with keratin pearls, I kept running across this on Qbank, but I really want to find a picture somewhere.
More common worldwide, but in the US adenocarcinoma is more common.
Gastric hypertrophy with protein loss, parietal cell atrophy, and increase in mucous cells. Precancerous. Rugae of stomach are so hypertrophied that they look like brain gyri.
Intestinal stomach adenocarcinoma
Associated with H pylori infection and dietary nitrosamines / smoked foods, tobacco smoking, achlorhydria, chronic gastritis, commonly on the lesser curvature. Looks like ulcer with raised margins.
Diffuse / signet ringadenocarcinoma of the stomach
Not associated with H pylori, signet ring cells, stomach wall grossly thickened and leathery (linitis plastica)
Involvement of the left supraclavicular node by metastasis from stomach
Bilateral metastases to the ovaries. Abundant mucus, signet ring cells of stomach cancer
Sister mary joseph nodule
Subcutaneous periumbilical metastasis of stomach cancer
Decreased plasma volume, leads to sloughing of gastric mucosa and brain injury.
Think burned by a curling iron.