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Flashcards in Teratogens Deck (27)
1

ACEIs

Renal damage.

How to remember: ACEI affects the kidney in adults too.

2

Alkylating agents

Absence of digits, multiple anomalies.

How to remember: You need digits to write with chALK.

3

Aminoglycosides

CN VIII Toxicity.

How to remember: A mean guy hit the baby in the ear.

4

Carbamazepine

Neural tube defects
Craniofacial defects
Fingernail hypoplasia
Developmental delay
IUGR
Similar to hydantoin syndrome from phenytoin.

How to remember: The baby hid in the maze in the fens but then couldn't get out so he tried to scratch his way out and lost all his NAILS -- he grew bigger in the maze -- too big -- IUGR. He was DEVELOPMENTALLY DELAYED because he had no one to play with.

5

Diethylstilbestrol (DES)

Vaginal clear cell adenocarcinoma
Congenital Mullerian anomalies

How to remember: Stillbestrol sounds like still born ---> reproductive tract problems --> congenital mullerian anomalies...

6

Folate antagonists

Neural tube defects

7

Lithium

Ebstein anomaly, atrialized right ventricle

8

Methimazole

What this is: antithyroid drug known for causing agranulocytosis, like propylthiouracil.

Causes aplastia cutis congenita - absence of skin in a localized or widespread area at birth.

How to remember: A THIMBLE full of ACID would cause your skin to peel off!

9

Phenytoin

Neural tube defects
Craniofacial defects
Fingernail hypoplasia
Developmental delay
IUGR
Similar to hydantoin syndrome from phenytoin.

How to remember: The baby hid in the maze in the fens but then couldn't get out so he tried to scratch his way out and lost all his NAILS -- he grew bigger in the maze -- too big -- IUGR. He was DEVELOPMENTALLY DELAYED because he had no one to play with.

10

Tetracyclines

Discolored teeth, inhibition of bone growth

How to remember: Teethracyclines!

11

Thalidomide

Limb defects - phocomelia, micromelia, flipper limbs

How to remember: Thalimbdomide

12

Valproate

Inhibition of maternal folate absorption - neural tube defects

13

Warfarin

Bone deformities, fetal hemorrhage, abortion, opthalmologic abnormalities

Bone, Blood, Bort, Beam

14

Alcohol

Fetal alcohol syndrome
Intellectual disability
Retardation
Microcephaly
Holoprosencephaly
Facial abnormalities - smooth philtrum, thin upper lip, small palpebral fissures
Hypertelorism - increased distance between the eyes
Limb dislocation
Heart defects

15

Cocaine

Abnormal fetal growth and fetal addiction
Placental abruption - think vasoconstriction

16

Smoking (nicotine, CO)

Leading cause of low birth weight in developed countries
Associated with preterm labor, placental problems, IUGR, ADHD

17

Iodine

Excess or lack can lead to congenital goiter or hypothyroidism / cretinism

How to remember - P3UB TONGUE
Puffy
Pot-bellied
Pale
Umbilical protrusion
Brain problems
Tongue protrusion

18

Maternal diabetes

Caudal regression syndrome, anal atresia to sirenomelia, CHD, neural tube defects

Remember: Sirens are sweet

19

Vitamin A excess

Extremely high risk for spontaneous abortions and birth defects (cleft palate, cardiac abnormalities).

Remember: Vitamin A --> Retinoic acid --> migration badness

20

X-rays

Microcephaly, intellectual disability

21

Antibiotics to avoid in pregnancy

The Greasy River Flowed Clear Aminute after Sophie Treated it with Chlorine

Griseofulvin
Ribavirin
Fluoroquinolones
Clarithromycin
Aminoglycosides
Sulfonamides
Tetracyclines
Chloramphenacol

22

Sulfonamides

Kernicterus - means very high levels of bilirubin

Remember: Sulfonamides --> sulfur (yellow) --> jaundice

23

Fluoroquinolones

Cartilage damage

Remember: Fleur was walking alone when she damaged her cart.

24

Clarithromycin

Embryotoxic

25

Ribavarin

Teratogenic

26

Griseofulvin

Teratogenic

27

Chloramphenicol

Gray baby

Remember: If you wash your elephant with chlorine, it's still going to look gray.