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Flashcards in GI drugs Deck (12):
1

H2 blockers (names, use tox)

cimetidine, ranitidine, famotidine, nizatidine
- peptic ulcers, gastritis, mild GERD
- cimetidine is a p450 inhibitor and has anti-androgen effects
- both cimetidine and rantidine have decreased renal excretion of creatinine
- others dont really have side effects

2

PPIs

- prazoles
- inhibit H/K ATPase in stomach parietal cells irreversibly
- used in peptic ulcers, gastritis, esophageal reflux, Z-E syndrome
- increased risk of C. diff infection, pneumonia
- hip fractures and decreased serum Mg with long-term use

3

bismuth, sucralfate

bind to ulcer base, providing physical protection and allowing HCO3- secretion to reestablish pH gradient in the mucous layer
- used to increase ulcer healing, and in travelers diarrhea

4

misoprostol

PGE1 analog used to increase production and secretion of gastric mucous barrier and decrease acid production
- used in prevention of NSAID ulcers
- tox: diarrhea, abortifactant

5

octreotide

- somatostatin analog
- used in acute variceal bleeds, acromegaly, VIPoma, and carcinoid tumors
- tox: nausea, cramps, steatorrhea

6

aluminum hydroxide

- antacid that can cause hypokalemia, constipation, hypophosphatemia, proximal muscle weakness, osteodystrophy and seizures

7

calcium carbonate

- antacid that can cause hypokalemia, hypercalcemia and rebound increase in acid

8

magnesium hydroxide

- antacid that can cause hypokalemia, diarrhea, hyporeflexia, hypotension, cardiac arrest

9

osmotic laxatives

- mg hydroxide, mg citrate, polyethylene glycol, lactulose
- provide osmotic load to draw water out (same mech as lactase def)
- used in constipation
- SE: diarrhea, dehydration, may be abused by bulimics

10

sulfasTalazine

- a combination of sulfapyridine (antibacterial) and 5-aminosalicylic acid (anti-inflammatory)
- activated by colonic bacteria
- used in crohns and UC
- tox: malaise, nausea, sulfonamide tox, reversible oligospermia

11

ondansetron

- 5HT3 antagonist, decreases vagal stimulation
- powerful central antiemetic
- control vomiting postop and in patients undergoing cancer chemotherapy
- tox: headache, constipation

12

metoclopramide

- D2 receptor antagonist
- increased resting tone, contractility
- used in gastroparesis, antiemetic
- tox: increased parkinsonian effects, restlessness, drowsiness, fatigue, depression, nausea, diarrhea
- contraindicated with SBO or parkinsons