MSK + Skin Drugs Flashcards Preview

Step 1 Flash Cards > MSK + Skin Drugs > Flashcards

Flashcards in MSK + Skin Drugs Deck (15):
1

aspirin mechanism

- irreversibly inhibits COX by covalent acetylation, which decreases TXA2 and prostaglandin synthesis
- increased bleeding time, no effect on PTT and PT

2

aspirin clinical use

< 300mg/day - decreased platelet aggregation
300mg- 2400mg/day - antipyretic and analgesic
2400-4000mg/day - anti-inflammatory

3

aspirin tox

- gastric ulceration, tinnitus
- chronic renal failure, nephritis, upper GI bleeds
- Reye syndrome in kids
- hyperventilation and respiratory alkalosis

4

NSAIDs name and mech

- ibuprofen, naproxen, indomethacin, ketorolac, diclofenac
- reversibly inhibit COX1 and 2, block PG synthesis

5

NSAIDS clinical use and tox

- antipyretic, analgesic, anti-inflammatory
- indomethacin is used to close a PDA
- tox: interstitial nephritis, gastric ulcer, renal ischemia

6

COX2 inhibitors (celecoxib) mech

- reversibly inhibit COX2 (found in inflammatory cells and vascular endothelium)
- spares TXA2/platelet function and GI side effects

7

COX2 clinical use and tox

- RA and osteoarthritis, patients with gastritis or ulcers
- increased risk of thrombosis, sulfa allergy

8

acetaminophen

- reversibly inhibits COX, mostly CNS, inactivated peripherally
- antipyretic, analgesic but not anti-inflammatory
- tox: hepatic necrosis, NAPQI depletes glutathione, NAC regenerates it

9

bisphosphonates

- alendronate and other -ates
- pyrophosphate analogs, bind hydroxyapatite in bones, inhibiting osteoclast activity
- used in osteoporosis, hypercalcemia and Pagets disease
- tox: corrosive esophagitis, osteonecrosis of jaw

10

allopurinol

xanthine oxidase inhibitor
- prevents TLS and urate nephropathy, will increase concentrations of azathioprine and 6-MP

11

Rasburicase

recombinant urate oxidase used in TLS

12

febuxostat

inhibits xanthine oxidase

13

probenecid

inhibits reabsorption of uric acid in PCT (also inhibits secretion of penicillin)

14

colchicine

- inhibits microtubule polymerization, impairing leukocyte chemotaxis and degranulation
- good for acute gout and prophylaxis
- GI side effects, do not use in elderly peeps with renal dysfunction

15

entanercept

fusion protein (TNFa receptr + IgG Fc) used as decoy receptor for RA, psoriasis, ank spon