Psych Drugs Flashcards Preview

Step 1 Flash Cards > Psych Drugs > Flashcards

Flashcards in Psych Drugs Deck (17):
1

Methylphenidate, dextroamphetamine, methamphetamine, phentermine

CNS stimulants that increase catecholamines in the synaptic cleft, esp norepi and dopamine
- use: ADHD, narcolepsy, appetite control
- use for > 3 months associated with secondary pulmonary HTN

2

high potency typical antipsychotics

trifluoperazine, fluphenazine and haloperidol
(Try to Fly High)
- more EPS symptoms (treat with beztropine)

3

lower potency typical antipsychotics

chlorpromazine, thioridazine
(Cheating Thieves are LOW)
- more anticholinergic, antihistaminergic and anti-alpha adrenergic symptoms
- dry mouth, hypotension and sedation

4

mechanism and use of typical antipsychotics

- block D2 receptors
- used in schizophrenia, psychosis, acute mania, Tourettes

5

NMS

- rigidity, myoglobinuria, autonomic instability, hyperpyrexia
-treat with dantrolene and D2 agonists (bromocriptine)

6

tardive dyskinesia

- sterotypic oral-facial movements as a result of long-term antipsychotic use, potentially irreversible

7

atypical antipsychotic mech and use

- varied effects on 5HT, dopamine, alpha and H1 receptors
- used in schizophrenia, bipolar disorder, OCD, anxiety disorder, depression, mania and tourettes

8

atypical antipsychotic tox

- olanzapine/clozapine cause weight gain
- clozapine can cause agranulocytosis and seizure
- risoperidone increases prolactin
- ziprasidone prolongs the QT interval

9

lithium

- mechanism not established, possibly related to inhibition of phosphoinositol cascade
- used as mood stabilizer, also SIADH
- tox: tremor, sedation, edema, heart block, hypothyroidism, polyuria, teratogenesis
- narrow therapeutic window (watch out for thiazide diuretics, ACEi, NSAIDs)

10

buspirone

- 5HT1a receptor stimulator
- used in GAD
- does not cause sedation, addiction or tolerance and does not interact with alcohol
- takes 1-2 weeks to take effect

11

SSRI use and tox

- used in depression, GAD, panic disorder, OCD, bulimia, social phobias, PTSD
- tox: GI distress, sex dysfunction
- serotonin syndrome --> hyperthermia, confusion, myoclonus, CV collapse, flushing, diarrhea, seizures (treat with cyproheptadine)

12

SNRI names, use and tox

- venlafaxine, duloxetine
- used in depression, venlafaxine is also used in GAD and panic d/o, duloxetine is also indicated for diabetic peripheral neuropathy
- tox: inc in BP most common, also stimulant effects, sedation, nausea

13

TCA mech, clinical use and tox

- block reuptake of NE and 5HT
- use: major depression, OCD, fibromyalgia
- tox: sedation, alpha blocking effects --> hypotension, tachy, urinary retention, dry mouth
- 3 C's: convulsions, cardiotoxicity and coma
- treat with sodium bicarb in OD

14

MAOis

- used in atypical depression, anxiety and hypochondriasis
- tox: hypertensive crisis after eating tyramine, CNS stimulation

15

buproprion

- atypical antidepressant also used for smoking cessation
- increased NE and dopamine via unknown mech (structurally related to amphetamines)
- tox: stimulant effects, headache, seizures in bulimic pts
- no sexual side effects

16

mirtazapine

- alpha 2 antagonist and potent 5HT2/3 receptor antagonist
- tox: sedation, increased appetite, weight gain, dry mouth

17

trazodone

- primarily blocks 5HT2 and alpha-1 adrenergic receptors
- primarily used for insomnia, as high doses are needed for antidepressant effects
- tox: sedation, nausea, priapism, postural hypotension