Hematology Lecture

Question 1

A life sustaining fluid which circulates through the heart and blood vessels

Answer 1

Blood

Question 2

FORMED ELEMENTS

Answer 2

Includes erythrocytes, leukocytes, platelets and plasma

Question 3

is the fluid that remains after coagulation has occurred and clot has formed

Answer 3

serum

Question 4

is the liquid portion of unclotted blood

Answer 4

plasma

Question 5

Mesoblastic Stage chief site

Answer 5

yolk sac

Question 6

Mesoblastic Stage start day

Answer 6

19th day of Fetal Development after Fertilization

Question 7

Mesoblastic stage Predominant cell

Answer 7

PRIMITIVE ERYTHROBLAST (PE)

Question 8

will later differentiate into Adult Erythrocytes

Answer 8

NORMOBLASTIC CELL

Question 9

Hemoglobin present in mesoblastic stage

Answer 9

Portland, Gower 1, Gower 11

Question 10

a form of hemoglobin existing at low levels during embryonic and fetal life, composed of two zeta chains and two gamma chains. (2 zeta, 2 gamma)

Answer 10

portland

Question 11

is a form of hemoglobin existing only during embryonic life, and is the primary embryonic hemoglobin. It is composed of two zeta chains and two epsilon chains, and is relatively unstable, breaking down easily. (2 zeta, 2 epsilon)

Answer 11

gower 1

Question 12

is a form of hemoglobin existing at low levels during embryonic and fetal life. It is composed of two alpha chains and two epsilon chains, and is somewhat unstable, though not as much as hemoglobin Gower 1. (2 alpha, 2 epsilon)

Answer 12

gower 2

Question 13

is a continuous, regulated process of blood cell production

Answer 13

hematopoiesis

Question 14

Hepatic stage chief site

Answer 14

Liver

Question 15

hepatic stage starts

Answer 15

5th to 7th gestational weeks

Question 16

hepatic (Hematopoiesis during this phase occurs)

Answer 16

extravascularly

Question 17

The major site of T cell production, kidney and Spleen which produces B cells.

Answer 17

thymus

Question 18

The first fully developed organ in the fetus

Answer 18

thymus

Question 19

medullary stage chief site

Answer 19

Bone marrow

Question 20

start of medullary stage

Answer 20

4th and 5th month of fetal development

Question 21

at the end of the 6th month _______ is the end of hematopoiesis

Answer 21

bone marrow

Question 22

1st bone to demonstrate marrow hematopoietic activity

Answer 22

clavicle

Question 23

hemoglobin A

Answer 23

2 alpha, 2 beta

Question 24

hemoglobin B

Answer 24

2 alpha, 2 delta

Question 25

In adults, hematopoietic tissue is located in the

Answer 25

Bone marrow Lymph nodes Spleen Liver Thymus

Question 26

Thymus and is where T and B lymphocytes are derived

Answer 26

PRIMARY LYMPHOID TISSUE

Question 27

Where Lymphoid Cells respond to foreign antigens, consists of the spleen, lymph nodes and mucosa associated lymphoid tissue.

Answer 27

SECONDARY LYMPHOID CELLS

Question 28

Major function of BM is the

Answer 28

proliferation and production of blood cells

Question 29

4 Main Functions of Red Bone Marrow

Answer 29

Production of blood cells Destruction of erythrocytes Iron storage (from Hb breakdown) Central organ for B lymphocyte development

Question 30

Function in phagocytosis and secretion of various cytokines that regulate hematopoiesis

Answer 30

macrophages

Question 31

Secrete various steroids that influence erythropoiesis, maintain bone integrity and regulates the volume of marrow.

Answer 31

adipocytes

Question 32

Regulate the flow of particles entering and leaving hematopoietic spaces

Answer 32

endothelial cells

Question 33

Are bone-forming cells

Answer 33

osteoblasts

Question 34

Bone resorbing cells or destroying cells

Answer 34

osteoclasts

Question 35

Supports the vascular sinuses and developing hematopoietic cells

Answer 35

reticular cells (fibroblasts)

Question 36

a basic screening test and one of the most frequently ordered laboratory procedure.

Answer 36

CBC

Question 37

Test that measures the number of WBC in your body

Answer 37

wbc count

Question 38

important because RBCs contain Hgb which carries oxygen to your body tissue

Answer 38

RBC count

Question 39

Measurement of the concentration of Hgb in the blood

Answer 39

HGB DETERMINATION

Question 40

Can detect immature WBC and abnormalities, both of which are signs of potential issues.

Answer 40

differential count

Question 41

Volume of packed RBC that occupies a given volume of whole blood.

Answer 41

hematocrit

Question 42

Use to assess the erythropoietic activity of the bone marrow

Answer 42

reticulocyte count

Question 43

Rate at which red blood cells sediment in a period of one hour.

Answer 43

ERYTHROCYTE SEDIMENTATION RATE (ESR)

Question 44

activities done in prior to the examination of the specimen or sample that is intended to establish system conducive to accuracy testing

Answer 44

preventive

Question 45

activities done during testing to determine whether the test systems are performing correctly

Answer 45

assessment

Question 46

done when error is detected to correct the system.

Answer 46

corrective

Question 47

is the closeness to the estimated value to the true mean.

Answer 47

Accuracy

Question 48

is the reproducibility of a result, whether accurate or inaccurate.

Answer 48

precision

Question 49

GENERAL CHARACTERISTIC OF BLAST - Very dark blue and small in amount in comparison to the size of the nucleus. No granular is present

Answer 49

Cytoplasm

Question 50

large in size as compared to the size of cytoplasm. Chromatin which is reddish purple and indicates predominance of DNA

Answer 50

nucleus

Question 51

Is a process by which erythroid precursor cells differentiates to become mature.

Answer 51

ERYTHROPOIESIS

Question 52

Erythrocytes Shape: protein: lifespan: color: zone of pallor:

Answer 52

Anucleate, biconcave, discoid cells Hemoglobin 120 days salmon pink 1/3 of the center

Question 53

Hemoglobin Derivatives

Answer 53

* Carboxyhemoglobin * Methemoglobin * Sulfhemoglobin

Question 54

Tissue located within cavities of the cortical bone

Answer 54

bone marrow

Question 55

Secrete a semifluid extracellular matrix that serves to anchor developing hematopoietic cells in the bone cavity.

Answer 55

stromal cells