ANEMIA OF ABNORMAL IRON METABOLISM

Question 1

ANEMIA OF ABNORMAL IRON METABOLISM

Answer 1

• Microcytic
• Hypochromic

Question 2

necessary for the synthesis of normal
oxygen carrying hemoglobin.

Answer 2

Iron

Question 3

storage form of iron

Answer 3

SERUM FERRITIN

Question 4

• reflects the body tissue iron stores and thus a good indicator of iron storage status

Answer 4

SERUM FERRITIN

Question 5

first laboratory test to become abnormal

Answer 5

SERUM FERRITIN

Question 6

not helpful in the differentiation of IDA and Anemia of Chronic disorders because both have INCREASED values

Answer 6

FREE ERYTHROCYTE PROTOPORPHYRIN

Question 7

measure how much the RBC can bind iron

Answer 7

TOTAL IRON BINDING CAPACITY (TIBC)

Question 8

Transportation or iron throughout the body.

Answer 8

TRANSFERRIN SATURATION

Question 9

Computed as:

Answer 9

Serum Iron/TIBC x 100

Question 10

it is the last stage of iron deficiency

Answer 10

SERUM IRON

Question 11

Men -
Post menopausal women -
Pregnant -

Answer 11

10mg/day
20mg/day
30 - 75mg/day

Question 12

is a persistent, compulsive desire to eat a
single food or a non-food item such as starch or something crunchy such as ice, clay or plaster.

Answer 12

PICA

Question 13

cracks in the corners of the mouth

Answer 13

Angular stomatitis

Question 14

soreness of the tongue

Answer 14

Glossitis

Question 15

flattening and spooning of the nails

Answer 15

Koilonychia

Question 16

LABORATORY FINDINGS

Answer 16

• Decreased Hgb, Hct and RBC
• Decreased Indices
• Microcytic, hypochromic
• Elevated RDW
• Variable platelet count
• WBC and Reticulocyte count normal

Question 17

SHOULD BE DONE WITH _______

Answer 17

PRUSSIAN BLUE STAIN

Question 18

Hemoglobin values reach normal levels within

Answer 18

2 months

Question 19

Are a diverse group identified by a common feature of abnormal iron kinetics that produces excess accumulation of iron, which is deposited in the mitochondria of normoblasts

Answer 19

SIDEROBLASTIC ANEMIAS

Question 20

iron in the form of ferritin aggregates and at least 4 aggregates can be identified in approximately 50% of normoblasts

Answer 20

Type I

Question 21

contains 6 aggregates

Answer 21

type II

Question 22

pathologic ringed sideroblast

Answer 22

type III

Question 23

For a diagnosis of Sideroblastic anemia, at least

Answer 23

15% of normoblasts must be Type III ringed sideroblasts.

Question 24

ALA synthase deficiency

Answer 24

HEREDITARY (rare)

Question 25

cause is unknown, almost always related to anemia

Answer 25

Primary (idiopathic)

Question 26

Ex of primary

Answer 26

- Acute myeloid leukemia - Myelodysplastic syndromes - Myeloma

Question 27

Drugs used in the treatment of tuberculosis

Answer 27

- Isooniazid - Cycloserine - Pyrazinamide

Question 28

Occurs in children (ingestion of lead containing paint) and in adults (gasoline stations)

Answer 28

LEAD INTOXICATION

Question 29

deposit of iron in different organs of our body.

Answer 29

Hemosiderosis

Question 30

ANEMIA OF ABNORMAL NUCLEAR DEVELOPMENT

Answer 30

- Macrocytic - Normochromic

Question 31

represents 75% of cobalamin in the plasina

Answer 31

Adenosylcobalamin

Question 32

represents 75% of cobalamin in the liver robes, and the kidneys

Answer 32

Methylcobalamin

Question 33

is a rare X-linked disorder of purine metabolism caused by the lack of the enzyme xanthine-guanine phosphoribosyl transferase.

Answer 33

LESCH-NYHAN SYNDROME

Question 34

a rare hereditary autosomal recessive disorder of pyrimidine metabolism resulting in abnormal DNA synthesis, excessive urinary excretion of orotic acid, and megaloblastic anemia.

Answer 34

OROTIC ACIDURIA