Flashcards in Hematopoiesis Deck (16)
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1
What is the most common site of hematopoiesis at four months' gestation?
The liver
2
Sites of hematopoiesis in the bone marrow communicate with the blood vessels through ________ at sinusoids.
leaky blood vessels
3
Hematopoietic stem cells differentiate into ______ and _____.
myeloid stem cells; lymphoid stem cells
4
List the stages of hematopoiesis in a developing erythrocyte.
(1) Multipotent hematopoietic stem cell
(2) Myeloid stem cell
(3) Pronormoblast (or proerythroblast)
(4) Basophilic normoblast
(5) Polychromatophilic normoblast
(6) Orthochromatophilic normoblast
(7) Reticulocyte
(8) Erythrocyte
5
At which stage is the nucleus ejected in a developing erythrocyte?
Orthochromatophilic normoblast
6
The central pallor of a RBC should be roughly ___ the diameter of the cell.
1/3
7
Thrombopoietin is necessary for ______.
megakaryocyte maturation and platelet release
8
The largest hematopoietic cell is the ________.
megakaryocyte
9
List the stages of thrombopoiesis.
(1) Hematopoietic stem cell
(2) Myeloid stem cell
(3) Megakaryoblast
(4) Promegkaryocyte
(5) Megakaryocyte
(6) Platelet
10
What does G-CSF stand for?
Granulocyte Cell Stimulating Factor
11
List the stages of granulocyte development.
(1) Hematopoietic stem cell
(2) Myeloid stem cell
(3) Progenitor cell
(4) Myeloblast
(5) Promyelocyte
(6) Metamyelocyte
(7) Band
(8) Neutrophil, basophil, or eosinophil
12
What two cell signals are needed for mast cell differentiation?
Stem Cell Factor (SCF) and Interleukin-3 (IL-3)
13
B lymphoblasts develop into ______ and ______.
B cells and natural killer cells
14
The equation for cellularity of bone marrow is roughly _______.
100 - age
15
CFU-GEMM is _________.
the Colony-Forming Unit for Granulocytes/Erythrocytes/Monocytes/Megakaryocytes
16
