Chronic "Frustrated Immune Response" Flashcards Preview

MS1 - Blood & Lymph > Chronic "Frustrated Immune Response" > Flashcards

Flashcards in Chronic "Frustrated Immune Response" Deck (6)
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1

There are as many as _______ organisms in one milliliter of gut fluid.

10^12

2

Describe the factors that regulate the differentiation of Th0 cells in the Peyer’s Patches to Th1, Th2, or Th17 versus into Treg cells.

There is normally a lot of the cytokine TGFβ in the submucosal Peyer’s Patches, and that favors the differentiation of Th0 cells into Treg. The resident dendritic cells here make IL-10, and that also favors Treg development. Thus, there are a lot of Treg in the Peyer's patches.

3

What drives IgA production in the intestines?

The high prevalence of Tfh in Peyer's patches

4

How does the innate immune system switch from Treg to Th1, Th2, andn Th17?

The innate immune cells in the lining of the intestine secrete IL-6 which, in combination with TGF-beta, promotes the switch from Treg to the others.

5

What produces IL-6?

Damaged epithelial cells

6

Celiac patients develop a skin condition called ________, caused by IgA.

dermatitis herpetiformis

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