Disorders of Granulocyte/Monocyte Number Flashcards Preview

MS1 - Blood & Lymph > Disorders of Granulocyte/Monocyte Number > Flashcards

Flashcards in Disorders of Granulocyte/Monocyte Number Deck (21):
1

Monocytes are usually in the bloodstream for ______ days before moving into tissue.

3-5 days

2

Describe a monocyte.

Kidney-shaped nucleus, larger than RBCs

3

Neurophils are in the bone marrow for _____ until being released in the blood, where it resides for ______.

10 - 14 days; 6 hours

4

Neutropenia is _______.

a decrease in the absolute neutrophil count (including bands and segmented polymorphonuclear leukocytes), below accepted norms for age and other considerations

5

What is the range of normal for absolute neutrophil count?

1,000 - 3,000 / uL

6

What is the highest-risk stratification of neutropenia?

ANC

7

The most common cause of neutropenia is ________.

infection-associated

8

There are three mechanisms of secondary neutropenia causes: _________.

Immune (penicillin--acute); toxic (phenothiazine--chronic); and hypersensitivity (dilantin, phenobarbital--chronic)

9

What is the mechanism of alloimmune neutropenia?

Maternal antibodies cross-react with neonatal neutrophils, resulting in netropeniac infants that resolves 3-4 months after birth.

10

What three genetic situations can result in neutropenia?

Apoptosis of myeloid precursors associated with elastase (ELA-2), HAX-1, or other genes; rarely associated with G-CSF receptor defects

11

What are aphthous ulcers?

Cancre sores

12

List some of the viruses that can cause neutropenia.

EBV, HIV, CMV, hepatitis, measles, and varicella

13

What is Kostmann syndrome?

Hereditary defect of neutrophil production (apoptosis of myelocyte precursors, defects in G-CSF gene)

14

Autoimmune neutropenia, in which antibodies attack neutrophils, is found in _____.

systemic lupus erythematosus

15

How should neutropenia be treated?

Identify the source of infection (if fever is present) and treat with antibiotics; G-CSF can be given; remove toxins or drugs that might be causing neutropenia

16

What stages are most of the granulocytes in, in terms of the body's total reservoir?

Metamyelocyte, bands, and segmented

17

There are two types of neutropenia: _______.

I). that in which bone marrow reserves are depleted (can be primary or secondary), and II). that in which bone marrow reserves are normal (usually secondary)

18

Cyclic neutropenia is _______, while Shwachman-Diamond syndrome is ______.

autosomal dominant; autosomal recessive

19

"Left-shift" refers to an increase in _______.

bands and segmented neutrophils

20

List some of the categories of neutrophilia.

Increased production, increased release from marrow, reduced margination, and reduced egress from circulation

21

List some of the categories of eosinophilia.

Allergic disorders, tumors, parasitic infections, dermatitis, gastrointestinal disorders, hereditary disorders, and others

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