Type IV Immunopathology Flashcards Preview

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Flashcards in Type IV Immunopathology Deck (6)
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Define type IV immunopathology.

(n.) a form of autoimmunity mediated by T cells; formerly called delayed-type hypersensitivity; does not require antibody or B cells


Explain why a person usually has no observed symptoms when first exposed to a "contact sensitizer" like poison ivy.

Poison ivy irritation is a delayed-type hypersensitivity reaction, so one needs prior exposure to generate memory cells.


Explain the difference between initiation and elicitation.

Initiation creates memory T cells and elicitation excites those cells into action -- generating angry macrophages.


______, and not Th1, would be the predominate cell in a positive PPD at 48 hours.

Macrophages (because Th1 cells can stimulate 1,000 macrophages)


What does abacavir do in 8% of patients?

Changes the HLA B5701 (an MHC I) shape, causing CTLs to attack.


Hyperacute reactions occur when _________.

the host develops antibodies to the graft's MHC

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