Antibody Function and Complement Flashcards Preview

MS1 - Blood & Lymph > Antibody Function and Complement > Flashcards

Flashcards in Antibody Function and Complement Deck (21):
1

Humoral immunity refers to ________.

antibody-mediated immunity

2

Epitopes are usually _______.

ten to twenty amino acids long

3

The first immunoglobulin to be present in blood after an infection is ____, but later ____ is found in greater concentrations.

IgM; IgG

4

____ is the only antibody that the human fetus makes.

IgM

5

There are about _______ of IgG in the blood.

1,000 mg/dL

6

The plasma half-life of IgG is _____.

three weeks

7

IgE combats _____ and is involved in _______ reactions.

parasites; allergic

8

The alternative pathway (of complement activation) works by ____________.

activating C3 with molecules on the microbe's surface, thus activating C5 without needing antibody, C1, C4, or C2

9

Haptens are __________.

small molecules that elicit immunologic response

10

IgM is best at _______.

activating complement

11

IgG is best at _________.

activating phagocytosis (opsonization)

12

Secretory component keeps ___ from being degraded and comes from the ________.

IgA; receptor in epithelial cells that pumps IgA into mucous membranes

13

The classical pathway (of complement activation) is stimulated by ______.

IgG and IgM

14

Uticaria are ______.

"giant" hives

15

The classical pathway is regulated mainly by ________.

C1 esterase inhibitor

16

The alternate pathway is activated by _________.

two C3b molecules (from spontaneously lysing C3) being stabilized by properdin along with factor D -- notice that no antibody is required

17

Properdin binds to the _______.

cell walls of bacteria

18

The bacteria that are the most susceptible to MACs are _______.

Neisseria (gonorrhea, meningitis)

19

_______ is the opsonizing factor released in the complement cascade.

C3b

20

______ is chemotactic for phagocytic cells.

C5a

21

________ all bind to basophils/mast cells and induce histamine release.

C3a, C4a, and C5a

Decks in MS1 - Blood & Lymph Class (60):