Flashcards in Antibody Function and Complement Deck (21)
Humoral immunity refers to ________.
Epitopes are usually _______.
ten to twenty amino acids long
The first immunoglobulin to be present in blood after an infection is ____, but later ____ is found in greater concentrations.
____ is the only antibody that the human fetus makes.
There are about _______ of IgG in the blood.
The plasma half-life of IgG is _____.
IgE combats _____ and is involved in _______ reactions.
The alternative pathway (of complement activation) works by ____________.
activating C3 with molecules on the microbe's surface, thus activating C5 without needing antibody, C1, C4, or C2
Haptens are __________.
small molecules that elicit immunologic response
IgM is best at _______.
IgG is best at _________.
activating phagocytosis (opsonization)
Secretory component keeps ___ from being degraded and comes from the ________.
IgA; receptor in epithelial cells that pumps IgA into mucous membranes
The classical pathway (of complement activation) is stimulated by ______.
IgG and IgM
Uticaria are ______.
The classical pathway is regulated mainly by ________.
C1 esterase inhibitor
The alternate pathway is activated by _________.
two C3b molecules (from spontaneously lysing C3) being stabilized by properdin along with factor D -- notice that no antibody is required
Properdin binds to the _______.
cell walls of bacteria
The bacteria that are the most susceptible to MACs are _______.
Neisseria (gonorrhea, meningitis)
_______ is the opsonizing factor released in the complement cascade.
______ is chemotactic for phagocytic cells.