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MS1 - Blood & Lymph > Osteoarthritis > Flashcards

Flashcards in Osteoarthritis Deck (12):
1

What is osteoarthritis?

A disorder characterized by destruction of cartilage and subsequent hypertrophy of bone; it is the end stage of all types of arthritis

2

Hypertrophic bony spurs are called _______.

osteophytes

3

Osteoarthritis symptoms typically _____ with rest.

improve

4

Enlarged PIPs are called ______; enlarged DIPs are called ______.

Bouchard's nodes; Heberden's nodes

5

Other than Bouchard's and Heberden's nodes, what bony deformities are suggestive of osteoarthritis?

(1) squaring of the 1st carpometacarpal joint; (2) genu varus; (3) hallux valgus -- bunion; (4) cervical and lumbar spondylosis (a generic term for wearing down of the spinal disks)

6

Lab findings that point to osteoarthritis are _________.

negative crystals, normal viscosity, WBCs between 200 and 2,000, and normal glucose

7

Younger than 45, _______ predominate, while older than 45 _______ predominate.

men; women

8

Osteoarthritis primarily affects ________.

weight-bearing joints and joints that are highly used

9

Cartilage has no _____ and no ________.

vasculature; nerves

10

90% of the collagen in cartilage is ________.

type II

11

____ are major promoters of inflammation in osteoarthritis.

IL-1 and TNF alpha

12

IL-1 and TNF-alpha stimulate ________.

matrix metalloproteases

Decks in MS1 - Blood & Lymph Class (60):