Rheumatoid Arthritis Flashcards Preview

MS1 - Blood & Lymph > Rheumatoid Arthritis > Flashcards

Flashcards in Rheumatoid Arthritis Deck (15):
1

Rheumatoid arthritis is ______________.

a systemic, inflammatory, autoimmune disorder of unknown etiology that results predominantly in a peripheral, symmetric, inflammatory synovitis often leading to cartilage and bone destruction and joint deformities

2

RA is a disease of mostly ___________, but medium and large joints are sometimes affected.

small joints (except DIP)

3

RA often affects the ________ joint of the spine.

C1-C2

4

Rheumatoid factor is present in ______ percent of cases of RA.

85

5

Two non-articular conditions commonly found with RA are ___________.

anemia and hypergammaglobulinemia

6

_________ are highly specific to RA, but are only found in 70% of cases.

Anti-CCP antibodies (which react against peptides containing citrulline, a modified amino acid)

7

Arthrocentisis will reveal ________ in patients with RA.

WBCs > 2,000 /uL (mostly neutrophils) and low glucose and low complement

8

Extra-articular findings of RA can include __________.

fatigue, malaise, anorexia, weight loss, low-grade fever

9

The most common genetic marker of RA is ________.

HLA-DR4

10

Women have a(n) _________ incidence compared to men.

increased (2.5)

11

Type A cells are _________, while type B cells are _______.

macrophages; fibroblasts

12

Rheumatoid arthritis has a genetic correlation with _________.

QKRAA (the third hypervariable region)

13

TNF-alpha, IL-17, and IL-1 also stimulate ___________.

receptor activator of nuclear factor kappa-B ligand, which then activates osteoclasts

14

Rheumatoid factor is __________.

an antibody that recognizes the Fc region of IgG (most are IgM, but some can can IgG and IgA)

15

There are four main elements to treating rheumatoid arthritis: ________________.

NSAIDs, DMARDs, physical therapy, and surgery

Decks in MS1 - Blood & Lymph Class (60):