Rheumatoid Arthritis Flashcards Preview

MS1 - Blood & Lymph > Rheumatoid Arthritis > Flashcards

Flashcards in Rheumatoid Arthritis Deck (15)
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1
Q

Rheumatoid arthritis is ______________.

A

a systemic, inflammatory, autoimmune disorder of unknown etiology that results predominantly in a peripheral, symmetric, inflammatory synovitis often leading to cartilage and bone destruction and joint deformities

2
Q

RA is a disease of mostly ___________, but medium and large joints are sometimes affected.

A

small joints (except DIP)

3
Q

RA often affects the ________ joint of the spine.

A

C1-C2

4
Q

Rheumatoid factor is present in ______ percent of cases of RA.

A

85

5
Q

Two non-articular conditions commonly found with RA are ___________.

A

anemia and hypergammaglobulinemia

6
Q

_________ are highly specific to RA, but are only found in 70% of cases.

A

Anti-CCP antibodies (which react against peptides containing citrulline, a modified amino acid)

7
Q

Arthrocentisis will reveal ________ in patients with RA.

A

WBCs > 2,000 /uL (mostly neutrophils) and low glucose and low complement

8
Q

Extra-articular findings of RA can include __________.

A

fatigue, malaise, anorexia, weight loss, low-grade fever

9
Q

The most common genetic marker of RA is ________.

A

HLA-DR4

10
Q

Women have a(n) _________ incidence compared to men.

A

increased (2.5)

11
Q

Type A cells are _________, while type B cells are _______.

A

macrophages; fibroblasts

12
Q

Rheumatoid arthritis has a genetic correlation with _________.

A

QKRAA (the third hypervariable region)

13
Q

TNF-alpha, IL-17, and IL-1 also stimulate ___________.

A

receptor activator of nuclear factor kappa-B ligand, which then activates osteoclasts

14
Q

Rheumatoid factor is __________.

A

an antibody that recognizes the Fc region of IgG (most are IgM, but some can can IgG and IgA)

15
Q

There are four main elements to treating rheumatoid arthritis: ________________.

A

NSAIDs, DMARDs, physical therapy, and surgery

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