CLL and Non-Hodgkin Lymphoma Flashcards Preview

MS1 - Blood & Lymph > CLL and Non-Hodgkin Lymphoma > Flashcards

Flashcards in CLL and Non-Hodgkin Lymphoma Deck (22):
1

What are the three B cell markers?

CD19, CD20, and CD22

2

The most common leukemia in the western world is ______.

chronic lymphocytic leukemia

3

CLL is defined as ______.

> 5 x 10^9 lymphocytes per liter for greater than three months

4

CLL has a median age of presentation of ______ and is twice as common in _____.

65 years; men

5

Most CLL patients display ______.

mild symptoms or no symptoms at all

6

CLL cells present as ________.

high N:C ratio, small, condensed chromatin

7

Follicular lymphoma is defined as ______.

neoplasm of germinal B cell origin

8

Follicular lymphoma has a _____ incidence in men and women and a median age of presentation of _____.

equal; 60 years

9

Follicular lymphoma is often caused by the ______ translocation.

t (14;18)

10

______ is a diagnostic test for follicular lymphoma.

BCL2 (when positive in germinal B cells)

11

Mantle cells surround ______.

germinal centers

12

Mantle cell lymphomas typically express _______, but do not express ______.

CD5, CD19, and CD20; CD23 and cyclin D1 (BCL1)

13

Mantle cell lymphomas are _____ as common in men and have a median age of presentation of ______.

twice; 60 years

14

List the three common Burkitt lymphoma populations.

Endemic (in the malaria belt, among children, typically jaw and abdomen), sporadic (children or young adults, jaw or abdomen), and immunodeficiency-associated (HIV)

15

Burkitt lymphoma arises from _________.

germinal B cells

16

CLL is defined as an absolute lymphocyte count > ________.

5x10^9 for thee months

17

The most common genetic finding in CLL is ______.

del(13q14)

18

BCL6 and CD10 are two markers of _______.

germinal B cells and their derivative malignancies

19

Burkitt lymphoma has the "______" appearance with ________ cytoplasm.

starry-sky; basophilic

20

In _________, there is a complete effacement of lymph-node architecture.

diffuse large B cell lymphoma

21

Rouleaux formations are seen in _________.

myelomas

22

When lymph malignancies are positive for CD15 and CD30, what should you be thinking?

Hodgkin's

Decks in MS1 - Blood & Lymph Class (60):