Flashcards in CLL and Non-Hodgkin Lymphoma Deck (22):
1
What are the three B cell markers?
CD19, CD20, and CD22
2
The most common leukemia in the western world is ______.
chronic lymphocytic leukemia
3
CLL is defined as ______.
> 5 x 10^9 lymphocytes per liter for greater than three months
4
CLL has a median age of presentation of ______ and is twice as common in _____.
65 years; men
5
Most CLL patients display ______.
mild symptoms or no symptoms at all
6
CLL cells present as ________.
high N:C ratio, small, condensed chromatin
7
Follicular lymphoma is defined as ______.
neoplasm of germinal B cell origin
8
Follicular lymphoma has a _____ incidence in men and women and a median age of presentation of _____.
equal; 60 years
9
Follicular lymphoma is often caused by the ______ translocation.
t (14;18)
10
______ is a diagnostic test for follicular lymphoma.
BCL2 (when positive in germinal B cells)
11
Mantle cells surround ______.
germinal centers
12
Mantle cell lymphomas typically express _______, but do not express ______.
CD5, CD19, and CD20; CD23 and cyclin D1 (BCL1)
13
Mantle cell lymphomas are _____ as common in men and have a median age of presentation of ______.
twice; 60 years
14
List the three common Burkitt lymphoma populations.
Endemic (in the malaria belt, among children, typically jaw and abdomen), sporadic (children or young adults, jaw or abdomen), and immunodeficiency-associated (HIV)
15
Burkitt lymphoma arises from _________.
germinal B cells
16
CLL is defined as an absolute lymphocyte count > ________.
5x10^9 for thee months
17
The most common genetic finding in CLL is ______.
del(13q14)
18
BCL6 and CD10 are two markers of _______.
germinal B cells and their derivative malignancies
19
Burkitt lymphoma has the "______" appearance with ________ cytoplasm.
starry-sky; basophilic
20
In _________, there is a complete effacement of lymph-node architecture.
diffuse large B cell lymphoma
21
Rouleaux formations are seen in _________.
myelomas
22